hes1.L hes family bHLH transcription factor 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: hes1.L
Official Full Name: hes family bHLH transcription factor 1 L homeolog
Primary source: Xenbase:XB-GENE-865756
Locus tag: XELAEV_18027531mg
See related: EnsemblRapid:ENSXLAG00005034577 AllianceGenome:Xenbase:XB-GENE-865756
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: Xlh1; hes1; hes-1; hes1-a; hes1-b; Xhairy1; Xhairy-1
Summary: Enables bHLH transcription factor binding activity; protein heterodimerization activity; and sequence-specific DNA binding activity. Acts upstream of or within Notch signaling pathway; negative regulation of muscle organ development; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in mesenchyme; nervous system; and primary germ layer. Orthologous to human HES1 (hes family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 5L

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5L	NC_054379.1 (113862496..113864728, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5L	NC_030732.1 (103168903..103171135, complement)

Chromosome 5L - NC_054379.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In vitro, xHes1 protein can be phosphorylated by Cyclin-dependent-kinases. Under-phosphorylated xHes1 has enhanced inhibitory activity during neurogenesis. xHes1 reduces Ngn2 expression, protein stability and chromatin binding.
Title: N-terminal phosphorylation of xHes1 controls inhibition of primary neurogenesis in Xenopus.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables bHLH transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neurogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transcription factor HES-1-A

Names: Hairy and enhancer of split 1-A; Protein hairy-1; hairy and enhancer of split 1; hairy1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087927.1 → NP_001081396.1 transcription factor HES-1-A

See identical proteins and their annotated locations for NP_001081396.1

Status: PROVISIONAL

Source sequence(s)

BC070988

UniProtKB/Swiss-Prot

Q6IRB2, Q91635

UniProtKB/TrEMBL

A0A974HJQ8

Related

ENSXLAP00005103389.1, ENSXLAT00005105394.1

Conserved Domains (2) summary

cd00083
Location:32 → 93

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam07527
Location:110 → 148

Hairy_orange; Hairy Orange

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

113862496..113864728 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)