mapk1.L mitogen-activated protein kinase 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: mapk1.L
Official Full Name: mitogen-activated protein kinase 1 L homeolog
Primary source: Xenbase:XB-GENE-6252586
Locus tag: XELAEV_18007690mg
See related: EnsemblRapid:ENSXLAG00005012923
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: erk; Xp42; erk1; erk2; ert1; mapk; mpk1; mapk1; mapk2; prkm1; prkm2; mapk1b; mapk1-a; mapk1-b; p42mapk
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Genomic context

Location:: chromosome: 1L

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (167152483..167186921)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (154101188..154134365)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Xenopus p42 MAPK becomes phosphorylated in apoptotic eggs, however this modification does not activate the enzyme.
Title: Autophosphorylation of MAP kinase disables the MAPK pathway in apoptotic Xenopus eggs.
Here the authors show that CPEB4 activity is regulated by ERK2- and Cdk1-mediated hyperphosphorylation. These phosphorylation events additively activate CPEB4 in M-phase by maintaining it in its monomeric state.
Title: CPEB4 is regulated during cell cycle by ERK2/Cdk1-mediated phosphorylation and its assembly into liquid-like droplets.
The reciprocal feedback observed between MPF and ERK2 in meiosis is not observed during mitotic M-phase in cell-free Xenopus embryo extracts.
Title: Absence of reciprocal feedback between MPF and ERK2 MAP kinase in mitotic Xenopus laevis embryo cell-free extract.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of organelle organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitogen-activated protein kinase 1

Names: MAP kinase; mitogen-activated protein kinase 1b; myelin basic protein kinase-like protein

NP_001081344.1

EC 2.7.11.24

XP_041423626.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087875.1 → NP_001081344.1 mitogen-activated protein kinase 1

See identical proteins and their annotated locations for NP_001081344.1

Status: PROVISIONAL

Source sequence(s)

BC076730

UniProtKB/TrEMBL

Q6DFK6

Related

ENSXLAP00005038083.1, ENSXLAT00005038995.1

Conserved Domains (2) summary

smart00220
Location:28 → 316

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07849
Location:22 → 356

STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

167152483..167186921

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041567692.1 → XP_041423626.1 mitogen-activated protein kinase 1 isoform X1

UniProtKB/TrEMBL

A0A1L8I0W2, A0A974E260

Conserved Domains (1) summary

cd07849
Location:22 → 356

STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases