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pparg.L peroxisome proliferator activated receptor gamma L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 397769, updated on 18-Sep-2024

Summary

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Official Symbol
pparg.L
Official Full Name
peroxisome proliferator activated receptor gamma L homeolog
Primary source
Xenbase:XB-GENE-483140
See related
EnsemblRapid:ENSXLAG00005006053
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
nr1c3; pparg; xPPAR-gamma
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Genomic context

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See pparg.L in Genome Data Viewer
Location:
chromosome: 4L
Exon count:
8
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (154487766..154523981)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016765238.1 (11..288)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108704052 Neighboring gene synapsin II L homeolog Neighboring gene metalloproteinase inhibitor 4 Neighboring gene Raf-1 proto-oncogene, serine/threonine kinase L homeolog Neighboring gene makorin ring finger protein 2 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Xenopus peroxisome proliferator activated receptors: genomic organization, response element recognition, heterodimer formation with retinoid X receptor and activation by fatty acids. Krey G, et al. J Steroid Biochem Mol Biol, 1993 Dec. PMID 8274443
  2. Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Dreyer C, et al. Cell, 1992 Mar 6. PMID 1312391
  3. Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Escher P, et al. Endocrinology, 2001 Oct. PMID 11564675
  4. Conserved amino acids in the ligand-binding and tau(i) domains of the peroxisome proliferator-activated receptor alpha are necessary for heterodimerization with RXR. Gorla-Bajszczak A, et al. Mol Cell Endocrinol, 1999 Jan 25. PMID 10195690
  5. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of cholesterol storage IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peroxisome proliferator-activated receptor gamma
Names
PPAR gamma 2
PPAR-gamma
nuclear receptor subfamily 1 group C member 3
xPPAR gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087843.1 → NP_001081312.1  peroxisome proliferator-activated receptor gamma

    See identical proteins and their annotated locations for NP_001081312.1

    Status: PROVISIONAL

    Source sequence(s)
    M84163
    UniProtKB/Swiss-Prot
    P37234
    Related
    ENSXLAP00005018494.1, ENSXLAT00005018824.1
    Conserved Domains (3) summary
    cd06932
    Location:211 → 476
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:112 → 195
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:1 → 83
    PPARgamma_N; PPAR gamma N-terminal region

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    154487766..154523981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041589176.1 → XP_041445110.1  peroxisome proliferator-activated receptor gamma isoform X1

    UniProtKB/TrEMBL
    Q6PA31, Q98SF8
    Related
    ENSXLAP00005018417.1, ENSXLAT00005018727.1
    Conserved Domains (3) summary
    cd06932
    Location:211 → 476
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:112 → 195
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:1 → 83
    PPARgamma_N; PPAR gamma N-terminal region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37234.1 GenPept UniProtKB/Swiss-Prot:P37234

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