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ldlr.L low density lipoprotein receptor L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 397757, updated on 17-Aug-2024

Summary

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Official Symbol
ldlr.L
Official Full Name
low density lipoprotein receptor L homeolog
Primary source
Xenbase:XB-GENE-6252601
Locus tag
XELAEV_18004433mg
See related
EnsemblRapid:ENSXLAG00005001332
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
fhc; ldlr1; ldlcq2; ldlr-a; ldlr-b
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Genomic context

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Location:
chromosome: 3L
Exon count:
18
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (148551011..148567837)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016694872.1 (141836..158726)

Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene dynein light chain Tctex-type protein 2B Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 L homeolog Neighboring gene KN motif and ankyrin repeat domains 2 L homeolog Neighboring gene dedicator of cytokinesis protein 6 Neighboring gene golgin subfamily A member 6-like protein 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The low density lipoprotein receptor in Xenopus laevis. I. Five domains that resemble the human receptor. Mehta KD, et al. J Biol Chem, 1991 Jun 5. PMID 1709931
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome IEA
Inferred from Electronic Annotation
more info
  
part_of low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
low-density lipoprotein receptor 1
Names
LDL receptor-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087821.1 → NP_001081290.1  low-density lipoprotein receptor 1 precursor

    See identical proteins and their annotated locations for NP_001081290.1

    Status: PROVISIONAL

    Source sequence(s)
    M62976
    UniProtKB/Swiss-Prot
    Q99087
    UniProtKB/TrEMBL
    B7ZRZ8
    Related
    ENSXLAP00005004100.1, ENSXLAT00005004166.1
    Conserved Domains (7) summary
    smart00135
    Location:464 → 506
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:352 → 382
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:148 → 183
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:193 → 229
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:527 → 567
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:316 → 350
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00104
    Location:276 → 306
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    148551011..148567837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99087.1 GenPept UniProtKB/Swiss-Prot:Q99087

Gene LinkOut

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Molecular Biology Databases
Research Materials