hmgcr.L 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: hmgcr.L
Official Full Name: 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog
Primary source: Xenbase:XB-GENE-5840728
Locus tag: XELAEV_18008167mg
See related: EnsemblRapid:ENSXLAG00005005594 AllianceGenome:Xenbase:XB-GENE-5840728
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: hmgcr
Summary: Predicted to enable NADP binding activity and hydroxymethylglutaryl-CoA reductase (NADPH) activity. Predicted to act upstream of or within cholesterol biosynthetic process; coenzyme A metabolic process; and isoprenoid biosynthetic process. Predicted to be located in endoplasmic reticulum and peroxisomal membrane. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; coronary artery disease (multiple); diabetes mellitus (multiple); muscular disease (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 1L

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (200559409..200577199)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (187441547..187457532)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within coenzyme A metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within isoprenoid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sterol biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Names: HMG-CoA reductase

NP_001081280.1

EC 1.1.1.34

XP_041423337.1

EC 1.1.1.34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087811.1 → NP_001081280.1 3-hydroxy-3-methylglutaryl-coenzyme A reductase

See identical proteins and their annotated locations for NP_001081280.1

Status: PROVISIONAL

Source sequence(s)

M29258

UniProtKB/Swiss-Prot

P20715

UniProtKB/TrEMBL

B7ZR18

Related

ENSXLAP00005016518.1, ENSXLAT00005016814.1

Conserved Domains (3) summary

cd00643
Location:460 → 866

HMG-CoA_reductase_classI; Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)

TIGR00920
Location:1 → 883

2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase

cl21543
Location:88 → 218

MMPL; MMPL family

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

200559409..200577199

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041567403.1 → XP_041423337.1 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform X1

UniProtKB/TrEMBL

A0A974E272, B7ZR18, Q6GM79

Related

ENSXLAP00005016524.1, ENSXLAT00005016820.1

Conserved Domains (1) summary

TIGR00920
Location:1 → 883

2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase