U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

epb41.L erythrocyte membrane protein band 4.1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 397741, updated on 4-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
epb41.L
Official Full Name
erythrocyte membrane protein band 4.1 L homeolog
Primary source
Xenbase:XB-GENE-865471
Locus tag
XELAEV_18012488mg
See related
EnsemblRapid:ENSXLAG00005002248 AllianceGenome:Xenbase:XB-GENE-865471
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
4.1R; FPO2; FPO2a; epb41
Summary
Predicted to enable actin binding activity; calmodulin binding activity; and structural molecule activity. Predicted to act upstream of or within positive regulation of protein localization to cell cortex. Predicted to be located in cell cortex. Orthologous to human EPB41 (erythrocyte membrane protein band 4.1). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See epb41.L in Genome Data Viewer
Location:
chromosome: 2L
Exon count:
29
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2L NC_054373.1 (86541136..86660218, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2L NC_030726.1 (80998703..81086429, complement)

Chromosome 2L - NC_054373.1Genomic Context describing neighboring genes Neighboring gene serine/arginine-rich splicing factor 4 L homeolog Neighboring gene uncharacterized LOC108708225 Neighboring gene uncharacterized LOC108708226 Neighboring gene small nucleolar RNA SNORD103/SNORD85 Neighboring gene small nucleolar RNA SNORD103/SNORD85

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Protein 4.1 and its interaction with other cytoskeletal proteins in Xenopus laevis oogenesis. Carotenuto R, et al. Eur J Cell Biol, 2009 Jun. PMID 19304341
  2. Antisense RNA inhibits expression of membrane skeleton protein 4.1 during embryonic development of Xenopus. Giebelhaus DH, et al. Cell, 1988 May 20. PMID 2453290
  3. Membrane skeleton protein 4.1 in developing Xenopus: expression in postmitotic cells of the retina. Spencer M, et al. Dev Biol, 1990 Jun. PMID 2186944
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data hypothesize that protein 4.1 (4.1R) could function as a linker protein between cytokeratin and the actin-based cytoskeleton.
    Title: Protein 4.1 and its interaction with other cytoskeletal proteins in Xenopus laevis oogenesis.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of protein localization to cell cortex ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cell cortex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein 4.1
Names
band 4.1
cytoskeletal protein 4.1
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087795.1 → NP_001081264.1  protein 4.1

    See identical proteins and their annotated locations for NP_001081264.1

    Status: PROVISIONAL

    Source sequence(s)
    M20621
    UniProtKB/Swiss-Prot
    P11434
    UniProtKB/TrEMBL
    Q6DCU8
    Related
    ENSXLAP00005006783.1, ENSXLAT00005006892.1
    Conserved Domains (7) summary
    smart00295
    Location:194 → 384
    B41; Band 4.1 homologues
    cd13184
    Location:379 → 472
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:279 → 384
    FERM_M; FERM central domain
    pfam04382
    Location:605 → 651
    SAB; SAB domain
    pfam05902
    Location:693 → 799
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:482 → 524
    FA; FERM adjacent (FA)
    pfam09379
    Location:197 → 257
    FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054373.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    86541136..86660218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041580884.1 → XP_041436818.1  protein 4.1 isoform X4

    UniProtKB/TrEMBL
    A0A8J1M549, A0A974DMQ3
    Conserved Domains (3) summary
    smart00295
    Location:205 → 395
    B41; Band 4.1 homologues
    cd13184
    Location:390 → 483
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    NF033479
    Location:631 → 761
    Efa1_rel_toxin; LifA/Efa1-related large cytotoxin

  2. XM_041580897.1 → XP_041436831.1  protein 4.1 isoform X16

    UniProtKB/TrEMBL
    A0A8J1M697, Q6DCU8
    Related
    ENSXLAP00005006801.1, ENSXLAT00005006910.1
    Conserved Domains (2) summary
    smart00295
    Location:220 → 410
    B41; Band 4.1 homologues
    cd13184
    Location:405 → 497
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

  3. XM_041580896.1 → XP_041436830.1  protein 4.1 isoform X15

    UniProtKB/TrEMBL
    A0A8J1M707, Q6DCU8
    Conserved Domains (2) summary
    smart00295
    Location:220 → 410
    B41; Band 4.1 homologues
    cd13184
    Location:405 → 498
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

  4. XM_041580895.1 → XP_041436829.1  protein 4.1 isoform X14

    UniProtKB/TrEMBL
    A0A8J1M568, Q6DCU8
    Related
    ENSXLAP00005006797.1, ENSXLAT00005006906.1
    Conserved Domains (2) summary
    smart00295
    Location:220 → 410
    B41; Band 4.1 homologues
    cd13184
    Location:405 → 498
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

  5. XM_041580894.1 → XP_041436828.1  protein 4.1 isoform X13

    UniProtKB/TrEMBL
    A0A8J1M560, Q6DCU8
    Related
    ENSXLAP00005006794.1, ENSXLAT00005006903.1
    Conserved Domains (3) summary
    smart00295
    Location:220 → 410
    B41; Band 4.1 homologues
    cd13184
    Location:405 → 498
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    NF033479
    Location:571 → 701
    Efa1_rel_toxin; LifA/Efa1-related large cytotoxin

  6. XM_041580891.1 → XP_041436825.1  protein 4.1 isoform X10

    UniProtKB/TrEMBL
    A0A8J1M702, A0A974DMQ3
    Conserved Domains (3) summary
    smart00295
    Location:220 → 410
    B41; Band 4.1 homologues
    cd13184
    Location:405 → 498
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    NF033479
    Location:607 → 737
    Efa1_rel_toxin; LifA/Efa1-related large cytotoxin

  7. XM_041580890.1 → XP_041436824.1  protein 4.1 isoform X9

    UniProtKB/TrEMBL
    A0A8J1M563, A0A974DMQ3
    Conserved Domains (3) summary
    smart00295
    Location:220 → 410
    B41; Band 4.1 homologues
    cd13184
    Location:405 → 498
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    NF033479
    Location:610 → 740
    Efa1_rel_toxin; LifA/Efa1-related large cytotoxin

  8. XM_041580892.1 → XP_041436826.1  protein 4.1 isoform X11

    UniProtKB/TrEMBL
    A0A8J1M692, A0A974DMQ3
    Conserved Domains (3) summary
    PTZ00449
    Location:611 → 819
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00295
    Location:220 → 410
    B41; Band 4.1 homologues
    cd13184
    Location:405 → 498
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

  9. XM_041580888.1 → XP_041436822.1  protein 4.1 isoform X7

    UniProtKB/TrEMBL
    A0A8J1M556, A0A974DMQ3
    Conserved Domains (3) summary
    smart00295
    Location:220 → 410
    B41; Band 4.1 homologues
    COG3061
    Location:621 → 702
    OapA; Cell envelope opacity-associated protein A (function unknown) [Function unknown]
    cd13184
    Location:405 → 498
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

  10. XM_041580889.1 → XP_041436823.1  protein 4.1 isoform X8

    UniProtKB/TrEMBL
    A0A8J1M554, A0A974DMQ3
    Conserved Domains (3) summary
    PTZ00449
    Location:611 → 833
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00295
    Location:220 → 410
    B41; Band 4.1 homologues
    cd13184
    Location:405 → 498
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

  11. XM_041580883.1 → XP_041436817.1  protein 4.1 isoform X3

    UniProtKB/TrEMBL
    A0A8J1M551, A0A974DMQ3
    Conserved Domains (4) summary
    PTZ00449
    Location:611 → 854
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00295
    Location:220 → 410
    B41; Band 4.1 homologues
    cd13184
    Location:405 → 498
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    TIGR01347
    Location:614 → 730
    sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)

  12. XM_041580885.1 → XP_041436819.1  protein 4.1 isoform X5

    UniProtKB/TrEMBL
    A0A8J1M558, A0A974DMQ3
    Conserved Domains (3) summary
    smart00295
    Location:220 → 410
    B41; Band 4.1 homologues
    PHA03247
    Location:629 → 810
    PHA03247; large tegument protein UL36; Provisional
    cd13184
    Location:405 → 498
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

  13. XM_041580886.1 → XP_041436820.1  protein 4.1 isoform X6

    UniProtKB/TrEMBL
    A0A8J1M687, A0A974DMQ3
    Related
    ENSXLAP00005006767.1, ENSXLAT00005006876.1
    Conserved Domains (3) summary
    smart00295
    Location:194 → 384
    B41; Band 4.1 homologues
    cd13184
    Location:379 → 472
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    NF033479
    Location:620 → 750
    Efa1_rel_toxin; LifA/Efa1-related large cytotoxin

  14. XM_041580887.1 → XP_041436821.1  protein 4.1 isoform X6

    UniProtKB/TrEMBL
    A0A8J1M687, A0A974DMQ3
    Conserved Domains (3) summary
    smart00295
    Location:194 → 384
    B41; Band 4.1 homologues
    cd13184
    Location:379 → 472
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    NF033479
    Location:620 → 750
    Efa1_rel_toxin; LifA/Efa1-related large cytotoxin

  15. XM_041580882.1 → XP_041436816.1  protein 4.1 isoform X2

    UniProtKB/TrEMBL
    A0A8J1M680, A0A974DMQ3
    Conserved Domains (3) summary
    smart00295
    Location:218 → 408
    B41; Band 4.1 homologues
    cd13184
    Location:403 → 496
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    NF033479
    Location:644 → 774
    Efa1_rel_toxin; LifA/Efa1-related large cytotoxin

  16. XM_041580881.1 → XP_041436815.1  protein 4.1 isoform X1

    UniProtKB/TrEMBL
    A0A8J1M6Z4, A0A974DMQ3
    Conserved Domains (3) summary
    smart00295
    Location:194 → 384
    B41; Band 4.1 homologues
    cd13184
    Location:379 → 471
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    NF033479
    Location:619 → 749
    Efa1_rel_toxin; LifA/Efa1-related large cytotoxin

  17. XM_041580893.1 → XP_041436827.1  protein 4.1 isoform X12

    UniProtKB/TrEMBL
    A0A8J1M561, A0A974HW39
    Conserved Domains (3) summary
    smart00295
    Location:220 → 410
    B41; Band 4.1 homologues
    cd13184
    Location:405 → 498
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    NF033479
    Location:646 → 776
    Efa1_rel_toxin; LifA/Efa1-related large cytotoxin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11434.1 GenPept UniProtKB/Swiss-Prot:P11434

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials