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irf6.2.L interferon regulatory factor 6, gene 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 397715, updated on 4-Nov-2024

Summary

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Official Symbol
irf6.2.L
Official Full Name
interferon regulatory factor 6, gene 2 L homeolog
Primary source
Xenbase:XB-GENE-5910427
Locus tag
XELAEV_18027330mg
See related
EnsemblRapid:ENSXLAG00005034478 AllianceGenome:Xenbase:XB-GENE-5910427
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
irf6.2; xIRF-6
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within immune system process; positive regulation of DNA-templated transcription; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including Van der Woude syndrome; cleft lip; cleft palate; orofacial cleft 6; and popliteal pterygium syndrome. Orthologous to human IRF6 (interferon regulatory factor 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See irf6.2.L in Genome Data Viewer
Location:
chromosome: 5L
Exon count:
9
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5L NC_054379.1 (92280491..92291130, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5L NC_030732.1 (89999410..90010156, complement)

Chromosome 5L - NC_054379.1Genomic Context describing neighboring genes Neighboring gene ubiquitin protein ligase E3D L homeolog Neighboring gene trophoblast glycoprotein L homeolog Neighboring gene interferon regulatory factor 6 Neighboring gene uncharacterized LOC121393719

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An interferon regulatory factor-related gene (xIRF-6) is expressed in the posterior mesoderm during the early development of Xenopus laevis. Hatada S, et al. Gene, 1997 Dec 12. PMID 9426249
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC131101

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
interferon regulatory factor 6, gene 2 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087746.1 → NP_001081215.1  interferon regulatory factor 6, gene 2 L homeolog

    See identical proteins and their annotated locations for NP_001081215.1

    Status: PROVISIONAL

    Source sequence(s)
    BC108593
    UniProtKB/TrEMBL
    A0A974CXD0, Q2VPM3
    Conserved Domains (2) summary
    pfam00605
    Location:9 → 114
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:214 → 397
    IRF-3; Interferon-regulatory factor 3

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    92280491..92291130 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018261700.2 → XP_018117189.1  interferon regulatory factor 6, gene 2 L homeolog isoform X3

    UniProtKB/TrEMBL
    A0A8J0V984, A0A974CXD0

  2. XM_018261699.2 → XP_018117188.1  interferon regulatory factor 6, gene 2 L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J0V7Y2, A0A974CXD0
    Related
    ENSXLAP00005103096.1, ENSXLAT00005105100.1

  3. XM_018261698.2 → XP_018117187.1  interferon regulatory factor 6, gene 2 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0V4N2, A0A974CXD0
    Related
    ENSXLAP00005103070.1, ENSXLAT00005105074.1
    Conserved Domains (2) summary
    pfam00605
    Location:9 → 114
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:215 → 398
    IRF-3; Interferon-regulatory factor 3

  4. XM_041562096.1 → XP_041418030.1  interferon regulatory factor 6, gene 2 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0V4N2, A0A974CXD0
    Conserved Domains (2) summary
    pfam00605
    Location:9 → 114
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:215 → 398
    IRF-3; Interferon-regulatory factor 3
Nucleotide Protein Strain
Heading Accession and Version

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