bmpr1a.S bone morphogenetic protein receptor type 1A S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: bmpr1a.S
Official Full Name: bone morphogenetic protein receptor type 1A S homeolog
Primary source: Xenbase:XB-GENE-865539
Locus tag: XELAEV_18000668mg
See related: EnsemblRapid:ENSXLAG00005005584
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: alk3; skr5; alk-3; cd292; bmpr1a; acvrlk3
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Genomic context

Location:: chromosome: 7S

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	7S	NC_054384.1 (38608752..38669417)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016694810.1 (8499744..8557651, complement)

Chromosome 7S - NC_054384.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ALK3 and ALK6 both contribute to the gene regulatory network that regulates dorso-ventral patterning.
Title: Differential requirement of bone morphogenetic protein receptors Ia (ALK3) and Ib (ALK6) in early embryonic patterning and neural crest development.
Data show that USP15 enhances BMP-induced phosphorylation of SMAD1 by interacting with and deubiquitylating ALK3.
Title: USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables SMAD binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor activity	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor activity, type I	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within BMP signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bone morphogenetic protein receptor type 1A S homeolog

Names: BMP receptor; bone morphogenetic protein receptor type IA S homeolog; bone morphogenetic protein receptor, type 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087740.1 → NP_001081209.1 bone morphogenetic protein receptor type 1A S homeolog precursor

See identical proteins and their annotated locations for NP_001081209.1

Status: PROVISIONAL

Source sequence(s)

BC071081

UniProtKB/TrEMBL

O42339, Q91578

Related

ENSXLAP00005016545.1, ENSXLAT00005016841.1

Conserved Domains (2) summary

cd14220
Location:233 → 519

STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor

pfam01064
Location:61 → 132

Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054384.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

38608752..38669417

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041570413.1 → XP_041426347.1 bone morphogenetic protein receptor type 1A S homeolog isoform X3

UniProtKB/TrEMBL

A0A8J1L9Z4, Q91578

Conserved Domains (2) summary

cd14220
Location:201 → 487

STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor

cl11586
Location:27 → 97

snake_toxin; Snake toxin domain, present in short and long neurotoxins, cytotoxins and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and ...
XM_041570411.1 → XP_041426345.1 bone morphogenetic protein receptor type 1A S homeolog isoform X1

UniProtKB/TrEMBL

O42339, Q91578

Conserved Domains (2) summary

cd14220
Location:233 → 519

STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor

pfam01064
Location:61 → 132

Activin_recp; Activin types I and II receptor domain
XM_041570412.1 → XP_041426346.1 bone morphogenetic protein receptor type 1A S homeolog isoform X2

UniProtKB/TrEMBL

A0A8J1LA26, Q91578

Conserved Domains (2) summary

cd14220
Location:207 → 493

STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor

cl11586
Location:44 → 103

snake_toxin; Snake toxin domain, present in short and long neurotoxins, cytotoxins and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and ...
XM_041570414.1 → XP_041426348.1 bone morphogenetic protein receptor type 1A S homeolog isoform X3

UniProtKB/TrEMBL

A0A8J1L9Z4, Q91578

Conserved Domains (2) summary

cd14220
Location:201 → 487

STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor

cl11586
Location:27 → 97

snake_toxin; Snake toxin domain, present in short and long neurotoxins, cytotoxins and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and ...