HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: HMGCS2provided by VGNC
Official Full Name: 3-hydroxy-3-methylglutaryl-CoA synthase 2provided by VGNC
Primary source: VGNC:VGNC:109632
See related: Ensembl:ENSSSCG00000036808
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Biased expression in liver (RPKM 173.5) and mixtures (RPKM 59.8) See more
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Genomic context

Location:: chromosome: 4

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	4	NC_010446.5 (101420941..101440302)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	4	NC_010446.4 (111411282..111430642)

Chromosome 4 - NC_010446.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables hydroxymethylglutaryl-CoA synthase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in acetyl-CoA metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: hydroxymethylglutaryl-CoA synthase, mitochondrial

Names: 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial); HMG-CoA synthase

NP_999545.1

EC 2.3.3.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214380.2 → NP_999545.1 hydroxymethylglutaryl-CoA synthase, mitochondrial precursor

See identical proteins and their annotated locations for NP_999545.1

Status: PROVISIONAL

Source sequence(s)

U90884

UniProtKB/Swiss-Prot

A5GFY7, O02734

UniProtKB/TrEMBL

A0A8D0JYQ8

Related

ENSSSCP00000042638.2, ENSSSCT00000064945.3

Conserved Domains (3) summary

TIGR01833
Location:50 → 505

HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

pfam01154
Location:53 → 223

HMG_CoA_synt_N; Hydroxymethylglutaryl-coenzyme A synthase N terminal

pfam08540
Location:224 → 506

HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal