U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Taf4 TBP-associated factor 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39765, updated on 3-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Taf4provided by FlyBase
Official Full Name
TBP-associated factor 4provided by FlyBase
Primary source
FLYBASE:FBgn0010280
Locus tag
Dmel_CG5444
See related
AllianceGenome:FB:FBgn0010280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5444; d110; Dmel\CG5444; dmTAF4; dTAF4; dTAFII110; dTAF[[II]]110; l(3)72Dj; p110; SR3-3; SY3-2 TAF110; TAF; taf110; Taf110; TAF110; taf4; TAF4; TAFII110; TAF[II]110; TAF[[II]]; Taf[[II]]110; TAF[[II]]110; TFIID; TFIID 110
Summary
Enables DNA binding activity; DNA-binding transcription factor binding activity; and TFIIA-class transcription factor complex binding activity. Contributes to RNA polymerase II general transcription initiation factor activity. Involved in transcription initiation at RNA polymerase II promoter. Located in nucleus. Part of transcription factor TFIID complex. Is expressed in epithelial cell; epithelium; male accessory gland; seminal vesicle; and testis. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and spermatogenic failure 13. Orthologous to several human genes including TAF4B (TATA-box binding protein associated factor 4b). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Taf4 in Genome Data Viewer
Location:
72D7-72D8; 3-44 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16113212..16121651)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16106312..16114751)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Zinc-finger protein at 72D Neighboring gene Strumpellin Neighboring gene Phosphoglucose mutase 1 Neighboring gene Signal sequence receptor beta

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Incorporation of Drosophila TAF110 into the yeast TFIID complex does not permit the Sp1 glutamine-rich activation domain to function in vivo. Keaveney M, et al. Genes Cells, 1999 Apr. PMID 10336691
  2. The two activation domains of the CCAAT-binding factor CBF interact with the dTAFII110 component of the Drosophila TFIID complex. Coustry F, et al. Biochem J, 1998 Apr 1. PMID 9512492, Free PMC Article
  3. The cAMP-regulated transcription factor CREB interacts with a component of the TFIID complex. Ferreri K, et al. Proc Natl Acad Sci U S A, 1994 Feb 15. PMID 7906413, Free PMC Article
  4. A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation. Gill G, et al. Proc Natl Acad Sci U S A, 1994 Jan 4. PMID 8278363, Free PMC Article
  5. Identifying mutations in Drosophila genes by direct sequencing of PCR products. Schlag EM, et al. Biotechniques, 1999 Aug. PMID 10457826

See all (143) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II general transcription initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables TFIIA-class transcription factor complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated transcription initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase II IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIID complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of transcription factor TFIID complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
TBP-associated factor 4
Names
CG5444-PA
CG5444-PB
CG5444-PC
CG5444-PD
CG5444-PE
CG5444-PF
CG5444-PG
CG5444-PH
CG5444-PI
TATA-associated factor 110
TBP associated factor 110
TBP-associated factor
TBP-associated factor 110
TBP-associated factor 110kD
Taf4-PA
Taf4-PB
Taf4-PC
Taf4-PD
Taf4-PE
Taf4-PF
Taf4-PG
Taf4-PH
Taf4-PI
lethal(3)72Dj

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16113212..16121651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079378.4 → NP_524102.1  TBP-associated factor 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524102.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P47825, P49845, Q0E8E3, Q1LZ31, Q8T9E0, Q9VUY7
    UniProtKB/TrEMBL
    E1JI11
    Related
    FBpp0075205
    Conserved Domains (2) summary
    smart00549
    Location:293 → 383
    TAFH; TAF homology
    pfam05236
    Location:675 → 917
    TAF4; Transcription initiation factor TFIID component TAF4 family

  2. NM_001144486.3 → NP_001137958.1  TBP-associated factor 4, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137958.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z060
    Conserved Domains (2) summary
    smart00549
    Location:460 → 550
    TAFH; TAF homology
    pfam05236
    Location:842 → 1084
    TAF4; Transcription initiation factor TFIID component TAF4 family

  3. NM_001274998.1 → NP_001261927.1  TBP-associated factor 4, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261927.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFP3
    Conserved Domains (2) summary
    smart00549
    Location:334 → 424
    TAFH; TAF homology
    pfam05236
    Location:716 → 958
    TAF4; Transcription initiation factor TFIID component TAF4 family

  4. NM_001274999.1 → NP_001261928.1  TBP-associated factor 4, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261928.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PI76
    Conserved Domains (2) summary
    smart00549
    Location:419 → 509
    TAFH; TAF homology
    pfam05236
    Location:801 → 1043
    TAF4; Transcription initiation factor TFIID component TAF4 family

  5. NM_176333.3 → NP_788511.1  TBP-associated factor 4, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788511.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V201
    Related
    FBpp0075207
    Conserved Domains (2) summary
    smart00549
    Location:223 → 313
    TAFH; TAF homology
    pfam05236
    Location:605 → 847
    TAF4; Transcription initiation factor TFIID component TAF4 family

  6. NM_001169982.2 → NP_001163453.1  TBP-associated factor 4, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163453.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P47825, P49845, Q0E8E3, Q1LZ31, Q8T9E0, Q9VUY7
    UniProtKB/TrEMBL
    E1JI11
    Conserved Domains (2) summary
    smart00549
    Location:293 → 383
    TAFH; TAF homology
    pfam05236
    Location:675 → 917
    TAF4; Transcription initiation factor TFIID component TAF4 family

  7. NM_206379.3 → NP_996101.1  TBP-associated factor 4, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996101.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V201
    Conserved Domains (2) summary
    smart00549
    Location:223 → 313
    TAFH; TAF homology
    pfam05236
    Location:605 → 847
    TAF4; Transcription initiation factor TFIID component TAF4 family

  8. NM_168651.3 → NP_730109.1  TBP-associated factor 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730109.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P47825, P49845, Q0E8E3, Q1LZ31, Q8T9E0, Q9VUY7
    UniProtKB/TrEMBL
    E1JI11
    Related
    FBpp0075206
    Conserved Domains (2) summary
    smart00549
    Location:293 → 383
    TAFH; TAF homology
    pfam05236
    Location:675 → 917
    TAF4; Transcription initiation factor TFIID component TAF4 family

  9. NM_001300148.1 → NP_001287077.1  TBP-associated factor 4, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287077.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P47825, P49845, Q0E8E3, Q1LZ31, Q8T9E0, Q9VUY7
    UniProtKB/TrEMBL
    E1JI11
    Conserved Domains (2) summary
    smart00549
    Location:293 → 383
    TAFH; TAF homology
    pfam05236
    Location:675 → 917
    TAF4; Transcription initiation factor TFIID component TAF4 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V201 A4V201
B7Z060 B7Z060
E1JI11 E1JI11
M9PFP3 M9PFP3
M9PI76 M9PI76
P47825.1 P47825

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous