PLCZ1 phospholipase C zeta 1 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: PLCZ1provided by VGNC
Official Full Name: phospholipase C zeta 1provided by VGNC
Primary source: VGNC:VGNC:103310
See related: Ensembl:ENSSSCG00000000590
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: PLC-zeta-1
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	5	NC_010447.5 (54257709..54452557)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	5	NC_010447.4 (57680677..57724905)

Chromosome 5 - NC_010447.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results might shed light on roles of these genes in spermatogenesis as candidate for boar sperm quality and fertility, but still the lack of association across populations should be considered.
Title: Investigation into association and expression of PLCz and COX-2 as candidate genes for boar sperm quality and fertility.
Results suggest a mechanism by which phospholipase C zeta originates from an oocyte-penetrating assembly--the sperm perinuclear matrix--to induce mammalian oocyte activation at fertilization.
Title: Mammalian phospholipase Czeta induces oocyte activation from the sperm perinuclear matrix.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration involved in egg activation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

Names: PLCZ; Phospholipase C-zeta-1; phosphoinositide phospholipase C-zeta-1; phospholipase c-zeta

NP_999515.1

EC 3.1.4.11

XP_020946833.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214350.1 → NP_999515.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

See identical proteins and their annotated locations for NP_999515.1

Status: PROVISIONAL

Source sequence(s)

AB113581

UniProtKB/Swiss-Prot

Q7YRU3

UniProtKB/TrEMBL

A0A4X1V6E7, A0A8D0M9C9

Related

ENSSSCP00000000621.3, ENSSSCT00000000635.4

Conserved Domains (4) summary

cd00275
Location:508 → 634

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

PLN02952
Location:71 → 632

PLN02952; phosphoinositide phospholipase C

pfam09279
Location:72 → 154

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

cl14615
Location:154 → 478

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010447.5 Reference Sscrofa11.1 Primary Assembly

Range

54257709..54452557

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021091174.1 → XP_020946833.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1

UniProtKB/TrEMBL

A0A4X1V6E7, A0A8D0M9C9

Conserved Domains (4) summary

cd15898
Location:32 → 62

EFh_PI-PLC; EF-hand motif [structural motif]

cl14615
Location:184 → 508

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

cl27705
Location:101 → 662

PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

cl28895
Location:32 → 130

EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes