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IleRS-m Isoleucyl-tRNA synthetase, mitochondrial [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39762, updated on 11-Sep-2024

Summary

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Official Symbol
IleRS-mprovided by FlyBase
Official Full Name
Isoleucyl-tRNA synthetase, mitochondrialprovided by FlyBase
Primary source
FLYBASE:FBgn0036569
Locus tag
Dmel_CG5414
See related
AllianceGenome:FB:FBgn0036569
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5414; Dmel\CG5414
Summary
Predicted to enable isoleucine-tRNA ligase activity. Predicted to be involved in isoleucyl-tRNA aminoacylation and mitochondrial translation. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human IARS2 (isoleucyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See IleRS-m in Genome Data Viewer
Location:
72D6-72D6; 3-44 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16100280..16103482)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16093380..16096582)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Chloride channel-c Neighboring gene uncharacterized protein Neighboring gene ATP synthase, beta subunit-like Neighboring gene Integrator 9 Neighboring gene uncharacterized protein Neighboring gene Zinc-finger protein at 72D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The aminoacyl-tRNA synthetases of Drosophila melanogaster. Lu J, et al. Fly (Austin), 2015. PMID 26761199, Free PMC Article
  2. Molecular genetic analyses of polytene chromosome region 72A-D in Drosophila melanogaster reveal a gene desert in 72D. Cooper MT, et al. PLoS One, 2011. PMID 21853143, Free PMC Article
  3. Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators. Pennemann FL, et al. Nat Commun, 2021 Dec 1. PMID 34853303, Free PMC Article
  4. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. Garapati PV, et al. Database (Oxford), 2019 Jan 1. PMID 30689844, Free PMC Article
  5. Laser microdissection of sensory organ precursor cells of Drosophila microchaetes. Buffin E, et al. PLoS One, 2010 Feb 19. PMID 20174573, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA editing activity IEA
Inferred from Electronic Annotation
more info
  
enables isoleucine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isoleucine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables isoleucine-tRNA ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in isoleucyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isoleucyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in isoleucyl-tRNA aminoacylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Isoleucyl-tRNA synthetase, mitochondrial
Names
CG5414-PB
IleRS-m-PB
NP_648837.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16100280..16103482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140580.2 → NP_648837.2  Isoleucyl-tRNA synthetase, mitochondrial [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648837.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4XVL0, Q9VUY4
    Conserved Domains (3) summary
    cd07960
    Location:668 → 842
    Anticodon_Ia_Ile_BEm; Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases
    PRK05743
    Location:26 → 938
    ileS; isoleucyl-tRNA synthetase; Reviewed
    cl00015
    Location:434 → 658
    nt_trans; nucleotidyl transferase superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VUY4 Q9VUY4

Gene LinkOut

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