IDH2 isocitrate dehydrogenase (NADP(+)) 2 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: IDH2provided by VGNC
Official Full Name: isocitrate dehydrogenase (NADP(+)) 2provided by VGNC
Primary source: VGNC:VGNC:111752
See related: Ensembl:ENSSSCG00000001852
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Broad expression in heart (RPKM 406.1), psoas major muscle (RPKM 349.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	7	NC_010449.5 (55654298..55675571, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	7	NC_010449.4 (60539333..60549480, complement)

Chromosome 7 - NC_010449.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase
Title: Critical role of Lys212 and Tyr140 in porcine NADP-dependent isocitrate dehydrogenase.
These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx activity.
Title: Mitochondrial NADP+-dependent isocitrate dehydrogenase protects cadmium-induced apoptosis.
analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase
Title: Location of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info	PubMed
enables isocitrate dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info	PubMed
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in isocitrate metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: isocitrate dehydrogenase [NADP], mitochondrial

Names: ICD-M; IDH; IDP; NADP(+)-specific ICDH; NADPH-specific isocitrate dehydrogenase; isocitrate dehydrogenase (NADP(+)) 2, mitochondrial; isocitrate dehydrogenase 2 (NADP+), mitochondrial; oxalosuccinate decarboxylase

NP_001157479.1

EC 1.1.1.42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164007.1 → NP_001157479.1 isocitrate dehydrogenase [NADP], mitochondrial

Status: PROVISIONAL

Source sequence(s)

AK233241

UniProtKB/TrEMBL

A0A286ZYE6, A0A4X1U136

Related

ENSSSCP00000036736.2, ENSSSCT00000044124.3

Conserved Domains (1) summary

PTZ00435
Location:39 → 451

PTZ00435; isocitrate dehydrogenase; Provisional