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HSD17B4 hydroxysteroid 17-beta dehydrogenase 4 [ Sus scrofa (pig) ]

Gene ID: 397574, updated on 17-Aug-2024

Summary

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Official Symbol
HSD17B4provided by VGNC
Official Full Name
hydroxysteroid 17-beta dehydrogenase 4provided by VGNC
Primary source
VGNC:VGNC:99760
See related
Ensembl:ENSSSCG00000028431
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Broad expression in liver (RPKM 158.9), kidney (RPKM 150.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See HSD17B4 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
24
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 2 NC_010444.4 (123313445..123401386)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 2 NC_010444.3 (128752284..128841343)

Chromosome 2 - NC_010444.4Genomic Context describing neighboring genes Neighboring gene Dmx like 1 Neighboring gene TNF alpha induced protein 8 Neighboring gene uncharacterized LOC110259451 Neighboring gene family with sequence similarity 170 member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Exogenous long-term treatment with 17β-oestradiol alters the innervation pattern in pig ovary. Koszykowska M, et al. Reprod Fertil Dev, 2013. PMID 22950857
  2. The membrane-bound 17β-estradiol dehydrogenase of porcine endometrial cells: purification, characterization and subcellular localization. Adamski J, et al. J Steroid Biochem Mol Biol, 1992 Dec. PMID 22217853
  3. Molecular cloning and amino acid sequence of the porcine 17 beta-estradiol dehydrogenase. Leenders F, et al. Eur J Biochem, 1994 May 15. PMID 8200347
  4. Supraphysiological leptin levels shift the profile of steroidogenesis in porcine ovarian follicles toward progesterone and testosterone secretion through increased expressions of CYP11A1 and 17b-HSD: a tissue culture approach. Gregoraszczuk EŁ, et al. Reproduction, 2013 Mar 1. PMID 23580952
  5. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exogenous long-term treatment with 17beta-oestradiol alters the innervation pattern in pig ovary.
    Title: Exogenous long-term treatment with 17β-oestradiol alters the innervation pattern in pig ovary.
  2. Leptin in elevated doses, by stimulatory effect on CYP11A1 and 17b-HSD protein expression resulting in elevated P(4) and testosterone secretions could be an independent risk factor for cyst formation in both prepubertal and cycling pigs.
    Title: Supraphysiological leptin levels shift the profile of steroidogenesis in porcine ovarian follicles toward progesterone and testosterone secretion through increased expressions of CYP11A1 and 17b-HSD: a tissue culture approach.
  3. isolation/purification of 17-beta-estradiol dehydrogenase from endometrium: molecular weight, isoenzyme forms, substrate specificity, subcellular localization to cytoplasmic vesicles
    Title: The membrane-bound 17β-estradiol dehydrogenase of porcine endometrial cells: purification, characterization and subcellular localization.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
peroxisomal multifunctional enzyme type 2
Names
17beta-estradiol dehydrogenase
NP_999471.1
XP_020937169.1
XP_020937173.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214306.1 → NP_999471.1  peroxisomal multifunctional enzyme type 2

    See identical proteins and their annotated locations for NP_999471.1

    Status: PROVISIONAL

    Source sequence(s)
    X78201
    UniProtKB/TrEMBL
    A0A480PUC2, A0A4X1UAJ1, Q28956
    Related
    ENSSSCP00000022446.2, ENSSSCT00000025027.4
    Conserved Domains (6) summary
    PLN02864
    Location:317 → 606
    PLN02864; enoyl-CoA hydratase
    cd05353
    Location:5 → 254
    hydroxyacyl-CoA-like_DH_SDR_c-like; (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs
    PRK05653
    Location:6 → 226
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated
    cd03448
    Location:486 → 606
    HDE_HSD; HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit.
    pfam02036
    Location:629 → 732
    SCP2; SCP-2 sterol transfer family
    cl00509
    Location:328 → 444
    hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010444.4 Reference Sscrofa11.1 Primary Assembly

    Range
    123313445..123401386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021081514.1 → XP_020937173.1  peroxisomal multifunctional enzyme type 2 isoform X2

    UniProtKB/TrEMBL
    A0A4X1UBD7
    Conserved Domains (3) summary
    PLN02864
    Location:200 → 489
    PLN02864; enoyl-CoA hydratase
    pfam02036
    Location:512 → 615
    SCP2; SCP-2 sterol transfer family
    cl25409
    Location:1 → 137
    SDR; Short-chain dehydrogenases/reductases (SDR)

  2. XM_021081510.1 → XP_020937169.1  peroxisomal multifunctional enzyme type 2 isoform X1

    UniProtKB/TrEMBL
    A0A8D1RL60
    Related
    ENSSSCP00000075447.1, ENSSSCT00000097174.1
    Conserved Domains (3) summary
    PLN02864
    Location:273 → 562
    PLN02864; enoyl-CoA hydratase
    cd05353
    Location:2 → 210
    hydroxyacyl-CoA-like_DH_SDR_c-like; (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs
    pfam02036
    Location:585 → 688
    SCP2; SCP-2 sterol transfer family
Nucleotide Protein
Heading Accession and Version

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