NPPA natriuretic peptide A [Sus scrofa (pig)] - Gene

Summary

Gene symbol: NPPA
Gene description: natriuretic peptide A
See related: Ensembl:ENSSSCG00000061442
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: ANF; ANP; CDD; CDP
Expression: Restricted expression toward heart (RPKM 96.6) See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 6

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	6	NC_010448.4 (71919557..71921345, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	6	NC_010448.3 (65829057..65830990, complement)

Chromosome 6 - NC_010448.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effect of insulin on natriuretic peptide gene expression in porcine heart.
Title: Effect of insulin on natriuretic peptide gene expression in porcine heart.
Atrial natriuretic peptide and vasopressin-presence in the ciliary body of eye in the pig (sus domesticus).
Title: Atrial natriuretic peptide and vasopressin-presence in the ciliary body of eye in the pig (sus domesticus).
ANP and BNP gene expression differs considerably between cardiac chambers in the first 72 hours of life in healthy piglets, resembling the transition from fetal to neonate circulation. The cardiac gene expression does not explain plasma concentrations.
Title: Cardiac natriuretic Peptide gene expression and plasma concentrations during the first 72 hours of life in piglets.
Up-regulation of ANP and a reduction in a ratio of sarcoplasmic reticulum calcium ATPase 2a and phospholamban in failing myocardium are observed in a porcine model of tachycardia.
Title: Development of porcine model of chronic tachycardia-induced cardiomyopathy.
Arial natriuretic factor (ANF) and N-terminal proANF may be better suited than brain natriuretic peptide as markers of cardiac preload during the development and treatment of acute heart failure.
Title: Cardiac secretion of atrial and brain natriuretic peptides in acute ischaemic heart failure in pigs: effect of angiotensin II receptor antagonism.
Stimulation of prepubertal granulosa cells with FSH resulted in a moderate expression of ANP. When FSH treatment was followed by LH, the pronounced expression of ANP was observed in all cells.
Title: Expression of atrial natriuretic peptide, progesterone, apoptosis-related proteins and caspase-3 in in vitro luteinized and leptin-treated porcine granulosa cells.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info	PubMed
enables hormone receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cGMP-mediated signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in receptor guanylyl cyclase signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: natriuretic peptides A

Names: atrial natriuretic factor prohormone; atrial natriuretic peptide prohormone; atriopeptigen; cardiodilatin; cardiodilatin-related peptide; natriuretic peptide precursor A; preproANF; preproANP; preproCDD-ANF; prepronatriodilatin; proANF; proANP

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214260.2 → NP_999425.1 natriuretic peptides A precursor

See identical proteins and their annotated locations for NP_999425.1

Status: PROVISIONAL

Source sequence(s)

X54669

UniProtKB/Swiss-Prot

P24259

UniProtKB/TrEMBL

A0A8D0MFA8

Conserved Domains (1) summary

smart00183
Location:122 → 145

NAT_PEP; Natriuretic peptide