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IGF1 insulin like growth factor 1 [ Sus scrofa (pig) ]

Gene ID: 397491, updated on 17-Aug-2024

Summary

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Official Symbol
IGF1provided by VGNC
Official Full Name
insulin like growth factor 1provided by VGNC
Primary source
VGNC:VGNC:98044
See related
Ensembl:ENSSSCG00000000857
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
IGF-1; IGF-I; Npt2B
Expression
Broad expression in subcutaneous adipose (RPKM 8.1), ovary (RPKM 2.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See IGF1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 5 NC_010447.5 (81762027..81909253)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 5 NC_010447.4 (85700439..85773714)

Chromosome 5 - NC_010447.5Genomic Context describing neighboring genes Neighboring gene phenylalanine hydroxylase Neighboring gene uncharacterized LOC106510404 Neighboring gene uncharacterized LOC110260785 Neighboring gene uncharacterized LOC110260784 Neighboring gene PARP1 binding protein Neighboring gene pro-melanin concentrating hormone Neighboring gene nucleoporin 37

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Sorbic acid improves growth performance and regulates insulin-like growth factor system gene expression in swine. Luo ZF, et al. J Anim Sci, 2011 Aug. PMID 21421836
  2. Nucleotide sequence of porcine insulin-like growth factor. 1:5' untranslated region, exons 1 and 2 and mRNA. Müller M, et al. Nucleic Acids Res, 1990 Jan 25. PMID 2326169, Free PMC Article
  3. Porcine insulin-like growth factor-I (pIGF-I): complementary deoxyribonucleic acid cloning and uterine expression of messenger ribonucleic acid encoding evolutionarily conserved IGF-I peptides. Tavakkol A, et al. Mol Endocrinol, 1988 Aug. PMID 3211153
  4. Assignment of the gene for porcine insulin-like growth factor 1 (IGF1) to chromosome 5 by linkage mapping. Winterø AK, et al. Anim Genet, 1994 Feb. PMID 8161019
  5. The porcine insulin-like growth factor-I gene: characterization and expression of alternate transcription sites. Weller PA, et al. J Mol Endocrinol, 1993 Oct. PMID 8297476

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRISPR/Cas9-Mediated Specific Integration of Fat-1 and IGF-1 at the pRosa26 Locus.
    Title: CRISPR/Cas9-Mediated Specific Integration of Fat-1 and IGF-1 at the pRosa26 Locus.
  2. A SNP in the 3'UTR of the porcine IGF-1 gene interacts with miR-new14 to affect IGF-1 expression, proliferation and apoptosis of PK-15 cells.
    Title: A SNP in the 3'UTR of the porcine IGF-1 gene interacts with miR-new14 to affect IGF-1 expression, proliferation and apoptosis of PK-15 cells.
  3. Role of Akt and mammalian target of rapamycin signalling in insulin-like growth factor 1-mediated cell proliferation in porcine Sertoli cells.
    Title: Role of Akt and mammalian target of rapamycin signalling in insulin-like growth factor 1-mediated cell proliferation in porcine Sertoli cells.
  4. This finding confirmed that miR-511 inhibits proliferation and promotes apoptosis by downregulating the IGF-1 in PK-15 cells.
    Title: A miR-511-binding site SNP in the 3'UTR of IGF-1 gene is associated with proliferation and apoptosis of PK-15 cells.
  5. High temperature, independent feed intake reduction, increases IGF-1:IGFBP-3 ratio.
    Title: Chronic heat stress increases insulin-like growth factor-1(IGF-1) but does not affect IGF-binding proteins in growing pigs.
  6. the dipeptide Pro-Asp promoted IGF-1 secretion and expression in hepatocytes.
    Title: The dipeptide Pro-Asp promotes IGF-1 secretion and expression in hepatocytes by enhancing JAK2/STAT5 signaling pathway.
  7. The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg. In summary, PPARg plays an important role in the regulation of IGF-1 secretion and gene expression in response to dietary protein.
    Title: Dietary protein-induced hepatic IGF-1 secretion mediated by PPARγ activation.
  8. Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.
    Title: Interrelationships between ovarian follicles grown in culture and possible mediators.
  9. This study demonstrated that Up-regulation of IGF-1 in the frontal cortex of piglets exposed to an environmentally enriched arena.
    Title: Up-regulation of IGF-1 in the frontal cortex of piglets exposed to an environmentally enriched arena.
  10. Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
    Title: Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin-like growth factor I
Names
somatomedin C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214256.1 → NP_999421.1  insulin-like growth factor I precursor

    See identical proteins and their annotated locations for NP_999421.1

    Status: VALIDATED

    Source sequence(s)
    M31175
    UniProtKB/TrEMBL
    Q0PPT2
    Conserved Domains (1) summary
    cd04368
    Location:26 → 93
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010447.5 Reference Sscrofa11.1 Primary Assembly

    Range
    81762027..81909253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021091138.1 → XP_020946797.1  insulin-like growth factor I isoform X3

    UniProtKB/TrEMBL
    A0A4X1T598
    Conserved Domains (1) summary
    cd04368
    Location:26 → 93
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...

  2. XM_005664197.3 → XP_005664254.1  insulin-like growth factor I isoform X4

    See identical proteins and their annotated locations for XP_005664254.1

    UniProtKB/TrEMBL
    A0A2C9F3F9, A0A4X1T5R2, A0A8D0UYR0, G9BFS5
    Related
    ENSSSCP00000030873.3, ENSSSCT00000035604.4
    Conserved Domains (1) summary
    cd04368
    Location:49 → 116
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

  3. XM_005664195.3 → XP_005664252.1  insulin-like growth factor I isoform X1

    See identical proteins and their annotated locations for XP_005664252.1

    UniProtKB/TrEMBL
    A0A287AC25, A0A288CFX8, A0A4X1T3B8, A0A8D0NN75, A0A8D1ETG0
    Related
    ENSSSCP00000041355.3, ENSSSCT00000050807.3
    Conserved Domains (1) summary
    cd04368
    Location:49 → 116
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

  4. XM_005664198.3 → XP_005664255.1  insulin-like growth factor I isoform X5

    See identical proteins and their annotated locations for XP_005664255.1

    UniProtKB/Swiss-Prot
    P16545
    UniProtKB/TrEMBL
    Q0PPT3, Q45QB4
    Related
    ENSSSCP00000000916.4, ENSSSCT00000000936.5
    Conserved Domains (1) summary
    cd04368
    Location:49 → 116
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

  5. XM_021091140.1 → XP_020946799.1  insulin-like growth factor I isoform X6

    UniProtKB/TrEMBL
    A0A8D1C5Z8, A0A8D1TX06, G9BFS6
    Conserved Domains (1) summary
    cd04368
    Location:49 → 116
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

  6. XM_005664196.3 → XP_005664253.1  insulin-like growth factor I isoform X2

    UniProtKB/TrEMBL
    A0A4X1T4H1, A0A4X1T598, A0A8D0KJC7, I3LBI3
    Related
    ENSSSCP00000021404.1, ENSSSCT00000023468.3
    Conserved Domains (1) summary
    cd04368
    Location:33 → 100
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

  7. XM_005664199.3 → XP_005664256.1  insulin-like growth factor I isoform X7

    See identical proteins and their annotated locations for XP_005664256.1

    UniProtKB/TrEMBL
    G9BFS9, Q0PPT2
    Conserved Domains (1) summary
    cd04368
    Location:33 → 100
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16545.1 GenPept UniProtKB/Swiss-Prot:P16545

Gene LinkOut

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