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HPD 4-hydroxyphenylpyruvate dioxygenase [ Sus scrofa (pig) ]

Gene ID: 397443, updated on 17-Aug-2024

Summary

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Official Symbol
HPDprovided by VGNC
Official Full Name
4-hydroxyphenylpyruvate dioxygenaseprovided by VGNC
Primary source
VGNC:VGNC:88960
See related
Ensembl:ENSSSCG00000009805
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Biased expression in liver (RPKM 465.2) and mixtures (RPKM 176.1) See more
Orthologs
human mouse all
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Genomic context

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See HPD in Genome Data Viewer
Location:
chromosome: 14
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 14 NC_010456.5 (30845608..30857658)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 14 NC_010456.4 (32650996..32662746)

Chromosome 14 - NC_010456.5Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 251 Neighboring gene proteasome 26S subunit, non-ATPase 9 Neighboring gene SET domain containing 1B, histone lysine methyltransferase Neighboring gene uncharacterized LOC110256740 Neighboring gene ras homolog family member F, filopodia associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Primary structure deduced from complementary DNA sequence and expression in cultured cells of mammalian 4-hydroxyphenylpyruvic acid dioxygenase. Evidence that the enzyme is a homodimer of identical subunits homologous to rat liver-specific alloantigen F. Endo F, et al. J Biol Chem, 1992 Dec 5. PMID 1339442
  2. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
  3. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 4-hydroxyphenylpyruvate dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tyrosine catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
4-hydroxyphenylpyruvate dioxygenase
Names
4-hydroxyphenylpyruvic acid dioxygenase
4-hydroxyphenylpyruvic acid oxidase
4HPPD
HPPDase
NP_001335893.1
XP_020927832.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348964.1 → NP_001335893.1  4-hydroxyphenylpyruvate dioxygenase

    Status: VALIDATED

    Source sequence(s)
    AEMK02000096, AK232923, CJ005279
    UniProtKB/TrEMBL
    A0A286ZK24, A0A4X1U570, A0A4X1UA55, A0A8D0ZRV9
    Related
    ENSSSCP00000031821.2, ENSSSCT00000048142.2
    Conserved Domains (1) summary
    TIGR01263
    Location:19 → 381
    4HPPD; 4-hydroxyphenylpyruvate dioxygenase

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010456.5 Reference Sscrofa11.1 Primary Assembly

    Range
    30845608..30857658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021072173.1 → XP_020927832.1  4-hydroxyphenylpyruvate dioxygenase isoform X1

    UniProtKB/TrEMBL
    A0A4X1UA55, A0A4X1UA71, A0A8D0I272, F1RNR6
    Related
    ENSSSCP00000010467.3, ENSSSCT00000010747.3
    Conserved Domains (1) summary
    cl28381
    Location:19 → 340
    HppD; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism, General function prediction only]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_214224.1: Suppressed sequence

    Description
    NM_214224.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02110.4 GenPept UniProtKB/Swiss-Prot:Q02110

Gene LinkOut

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