MMP2 matrix metallopeptidase 2 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: MMP2provided by VGNC
Official Full Name: matrix metallopeptidase 2provided by VGNC
Primary source: VGNC:VGNC:90274
See related: Ensembl:ENSSSCG00000002829
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: MMP-2
Expression: Broad expression in subcutaneous adipose (RPKM 402.8), ovary (RPKM 295.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	6	NC_010448.4 (30059247..30087031, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	6	NC_010448.3 (27526396..27553927, complement)

Chromosome 6 - NC_010448.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9, TIMP1, and NGAL (also MMP2 in 220 kDa complex) without proteolytic activity.
Title: Expression and complex formation of MMP9, MMP2, NGAL, and TIMP1 in porcine myocardium but not in skeletal muscles in male pigs with tachycardia-induced systolic heart failure.
Data demonstrate for the first time that MMP2 and MMP9 are expressed in swine ovarian follicle both in theca and granulosa layers.
Title: Gelatinases (MMP2 and MMP9) in swine antral follicle.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 and MMP-2, caspase-3 and BDNF
Title: Resuscitation of newborn piglets. short-term influence of FiO2 on matrix metalloproteinases, caspase-3 and BDNF.
MMP-2 may play an important role in regulating MLC1 turnover in the heart under normal physiological conditions.
Title: Cardiac dysfunction in an animal model of neonatal asphyxia is associated with increased degradation of MLC1 by MMP-2.
Oxygen for newborn resuscitation increases MMP-2/-9 activity resulting in tissue damage and influencing remodeling processes.
Title: Resuscitation of hypoxic newborn piglets with supplementary oxygen induces dose-dependent increase in matrix metalloproteinase-activity and down-regulates vital genes.
The expression of MMP2 and MMP9 in lung injury induced by mechanical stress, hypoxic injury, and septic shock in anesthetized swine are reported.
Title: In vivo study of the behaviour of matrix metalloproteinases (MMP-2, MMP-9) in mechanical, hypoxic and septic-induced acute lung injury.
The association results showed that the animals with the C allele of MMP2 have a significantly larger loin muscle area than that of the animals with the G allele (P < 0.05)
Title: The MMP2 gene may be associated with longissimus dorsi muscle area in the pig (Sus scrofa).
we cloned the 5'-upstream sequence, 3'-downstream sequence as well as other missed genomic sequences of porcine MMP-2, the genomic structure and the promotor sequence were analyzed and found to share high similarity with those of human MMP-2.
Title: Characterization of porcine MMP-2 and its association with immune traits.
In conclusion, thrombin activates pro-MMP-2 in the absence of elevated pro-MMP-2 expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2.
Title: Thrombin stimulates mitogenesis in pig cerebrovascular smooth muscle cells involving activation of pro-matrix metalloproteinase-2.
MMP-2 has a novel function in the degradation of the nuclear matrix in cigarette smoke-induced endothelial apoptosis.
Title: Nuclear localization of active matrix metalloproteinase-2 in cigarette smoke-exposed apoptotic endothelial cells.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Markers

MARC_41134-41135:1084210691:1 (e-PCR)
- UniSTS:471578

D16S2904 (e-PCR)
- UniSTS:153474

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in collagen catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info	PubMed
involved_in tissue remodeling	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 72 kDa type IV collagenase

Names: gelatinase A; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.