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MMP1 matrix metallopeptidase 1 [ Sus scrofa (pig) ]

Gene ID: 397320, updated on 5-Mar-2024

Summary

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Gene symbol
MMP1
Gene description
matrix metallopeptidase 1
See related
Ensembl:ENSSSCG00000014985
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
Mmp1a
Expression
Biased expression in kidney (RPKM 1.6), lung (RPKM 0.7) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See MMP1 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 9 NC_010451.4 (33411738..33420205, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 9 NC_010451.3 (37358454..37367107, complement)

Chromosome 9 - NC_010451.4Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 27 Neighboring gene matrix metallopeptidase 8 Neighboring gene matrix metallopeptidase 3 Neighboring gene matrix metallopeptidase 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Interruption of endothelin signaling modifies membrane type 1 matrix metalloproteinase activity during ischemia and reperfusion. Deschamps AM, et al. Am J Physiol Heart Circ Physiol, 2008 Feb. PMID 18065523, Free PMC Article
  2. Structure of full-length porcine synovial collagenase reveals a C-terminal domain containing a calcium-linked, four-bladed beta-propeller. Li J, et al. Structure, 1995 Jun 15. PMID 8590015
  3. Recombinant porcine collagenase: purification and autolysis. Clark IM, et al. Arch Biochem Biophys, 1995 Jan 10. PMID 7840605
  4. Nucleotide sequence of a cDNA for porcine type I collagenase, obtained by PCR. Clarke NJ, et al. Nucleic Acids Res, 1990 Nov 25. PMID 2174547, Free PMC Article
  5. Porcine collagenase from synovial fibroblasts: cDNA sequence and modulation of expression of RNA in vitro by various cytokines. Richards CD, et al. Matrix, 1991 Jun. PMID 1651440

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the identification of MMP1 and MMP10 genes in swine is reported.
    Title: Molecular characterization, mapping, and haplotype analysis of porcine matrix metalloproteinase genes MMP1 and MMP10.
  2. Results indicate that leukemia inhibitory factor (LIF) and Oncostatin M increase the expression of MMP-1, MMP-3, and TIMP-1 several fold, and that their expression is reduced to basal levels in the presence of the LIF antagonist MH35-BD.
    Title: Role of a LIF antagonist in LIF and OSM induced MMP-1, MMP-3, and TIMP-1 expression by primary articular chondrocytes.
  3. increased interstitial MMP1 activity during ischemia and reperfusion is a result of the endothelin protein kinase c pathway and may be due to enhanced phosphorylation of mmp1
    Title: Interruption of endothelin signaling modifies membrane type 1 matrix metalloproteinase activity during ischemia and reperfusion.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interstitial collagenase
Names
MMP-1
matix metalloproteinase I collagenase propeptide
matrix metallopeptidase 1 (interstitial collagenase)
matrix metalloproteinase 1 (type I collagenase)
matrix metalloproteinase-1
NP_001159701.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166229.1 → NP_001159701.1  interstitial collagenase precursor

    See identical proteins and their annotated locations for NP_001159701.1

    Status: PROVISIONAL

    Source sequence(s)
    EU722905
    UniProtKB/Swiss-Prot
    P21692
    UniProtKB/TrEMBL
    A0A8D1CIG7, C9VZX3
    Related
    ENSSSCP00000042817.1, ENSSSCT00000038101.2
    Conserved Domains (4) summary
    cd00094
    Location:275 → 466
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:108 → 261
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:108 → 261
    Peptidase_M10; Matrixin
    pfam01471
    Location:27 → 87
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010451.4 Reference Sscrofa11.1 Primary Assembly

    Range
    33411738..33420205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21692.2 GenPept UniProtKB/Swiss-Prot:P21692

Gene LinkOut

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