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ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 [ Sus scrofa (pig) ]

Gene ID: 397298, updated on 17-Aug-2024

Summary

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Official Symbol
ENTPD1provided by VGNC
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 1provided by VGNC
Primary source
VGNC:VGNC:97977
See related
Ensembl:ENSSSCG00000010497
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
CD39; ATP-DPH
Expression
Broad expression in spleen (RPKM 25.3), lung (RPKM 14.1) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 14
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 14 NC_010456.5 (107263546..107390923)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 14 NC_010456.4 (116897330..117022541)

Chromosome 14 - NC_010456.5Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 18 family member A1 Neighboring gene programmed cell death protein 2-like Neighboring gene tectonic family member 3 Neighboring gene coiled-coil and C2 domain containing 2B Neighboring gene uncharacterized LOC110256636 Neighboring gene cyclin J

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Distribution, cloning, and characterization of porcine nucleoside triphosphate diphosphohydrolase-1. Lemmens R, et al. Eur J Biochem, 2000 Jul. PMID 10866813
  2. Immunohistochemical and functional analysis of ectonucleoside triphosphate diphosphohydrolase 1 (CD39) and ecto-5'-nucleotidase (CD73) in pig aortic valves. Kaniewska E, et al. Nucleosides Nucleotides Nucleic Acids, 2014. PMID 24940684
  3. Identification and characterization of CD39/vascular ATP diphosphohydrolase. Kaczmarek E, et al. J Biol Chem, 1996 Dec 20. PMID 8955160
  4. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
  5. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD39 and CD73 and their enzymatic activities that convert extracellular nucleotides are highly expressed and could have special function in the valve
    Title: Immunohistochemical and functional analysis of ectonucleoside triphosphate diphosphohydrolase 1 (CD39) and ecto-5'-nucleotidase (CD73) in pig aortic valves.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GDP phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables UDP phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in nucleoside diphosphate catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ectonucleoside triphosphate diphosphohydrolase 1
Names
ATP-diphosphohydrolase
ATPDase
NTPDase 1
NTPDase1
ecto-ATP diphosphohydrolase 1
ecto-ATPDase 1
ecto-ATPase 1
ecto-apyrase
lymphoid cell activation antigen
nucleoside triphosphate diphosphohydrolase 1
NP_999318.1
XP_005671358.1
XP_005671360.1
XP_005671361.1
XP_013839039.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214153.1 → NP_999318.1  ectonucleoside triphosphate diphosphohydrolase 1

    See identical proteins and their annotated locations for NP_999318.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ133746
    UniProtKB/Swiss-Prot
    Q9MYU4
    UniProtKB/TrEMBL
    A0A0B8RZL3, A0A4X1UFD5, F1SC45
    Related
    ENSSSCP00000011184.3, ENSSSCT00000011485.4
    Conserved Domains (1) summary
    cl17037
    Location:40 → 470
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010456.5 Reference Sscrofa11.1 Primary Assembly

    Range
    107263546..107390923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005671301.3 → XP_005671358.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X1

    See identical proteins and their annotated locations for XP_005671358.1

    Conserved Domains (1) summary
    cl17037
    Location:1 → 362
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. XM_005671303.3 → XP_005671360.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X1

    See identical proteins and their annotated locations for XP_005671360.1

    Conserved Domains (1) summary
    cl17037
    Location:1 → 362
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  3. XM_005671304.3 → XP_005671361.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X1

    See identical proteins and their annotated locations for XP_005671361.1

    Conserved Domains (1) summary
    cl17037
    Location:1 → 362
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  4. XM_013983585.2 → XP_013839039.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X1

    Conserved Domains (1) summary
    cl17037
    Location:1 → 362
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9MYU4.1 GenPept UniProtKB/Swiss-Prot:Q9MYU4

Gene LinkOut

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Molecular Biology Databases
Research Materials