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MTHFR methylenetetrahydrofolate reductase [ Sus scrofa (pig) ]

Gene ID: 397180, updated on 17-Aug-2024

Summary

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Official Symbol
MTHFRprovided by VGNC
Official Full Name
methylenetetrahydrofolate reductaseprovided by VGNC
Primary source
VGNC:VGNC:90451
See related
Ensembl:ENSSSCG00000003428
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in ovary (RPKM 6.6), liver (RPKM 4.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See MTHFR in Genome Data Viewer
Location:
chromosome: 6
Exon count:
13
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (71863637..71882118, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 6 NC_010448.3 (65776804..65791405, complement)

Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene angiotensin II receptor associated protein Neighboring gene uncharacterized LOC110261388 Neighboring gene uncharacterized protein C1orf167 Neighboring gene chloride voltage-gated channel 6 Neighboring gene natriuretic peptide A Neighboring gene natriuretic peptide B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Effects of breed, parity, and folic Acid supplement on the expression of folate metabolism genes in endometrial and embryonic tissues from sows in early pregnancy. Vallée M, et al. Biol Reprod, 2002 Oct. PMID 12297544
  2. Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms. Tran P, et al. Mamm Genome, 2002 Sep. PMID 12370778
  3. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
  4. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylenetetrahydrofolate reductase (NAD(P)H) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
methylenetetrahydrofolate reductase
Names
5,10-methylenetetrahydrofolate reductase (NADPH)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

    Range
    71863637..71882118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003127574.4 → XP_003127622.1  methylenetetrahydrofolate reductase isoform X5

    See identical proteins and their annotated locations for XP_003127622.1

    UniProtKB/TrEMBL
    A0A287AUY4, A0A8D0HX37, A0A8D0HXW3, A0A8D1C5P6, F1RF82
    Related
    ENSSSCP00000047921.3, ENSSSCT00000037878.3
    Conserved Domains (1) summary
    cl00246
    Location:59 → 625
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  2. XM_005664995.3 → XP_005665052.1  methylenetetrahydrofolate reductase isoform X5

    See identical proteins and their annotated locations for XP_005665052.1

    UniProtKB/TrEMBL
    A0A287AUY4, A0A8D0HX37, A0A8D0HXW3, A0A8D1C5P6, F1RF82
    Conserved Domains (1) summary
    cl00246
    Location:59 → 625
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  3. XM_005664996.3 → XP_005665053.1  methylenetetrahydrofolate reductase isoform X5

    See identical proteins and their annotated locations for XP_005665053.1

    UniProtKB/TrEMBL
    A0A287AUY4, A0A8D0HX37, A0A8D0HXW3, A0A8D1C5P6, F1RF82
    Conserved Domains (1) summary
    cl00246
    Location:59 → 625
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  4. XM_021095344.1 → XP_020951003.1  methylenetetrahydrofolate reductase isoform X4

    UniProtKB/TrEMBL
    A0A8D0YSM6, A0A8D1YN60
    Conserved Domains (1) summary
    cl00246
    Location:59 → 663
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  5. XM_021095346.1 → XP_020951005.1  methylenetetrahydrofolate reductase isoform X4

    UniProtKB/TrEMBL
    A0A8D0YSM6, A0A8D1YN60
    Conserved Domains (1) summary
    cl00246
    Location:59 → 663
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  6. XM_021095345.1 → XP_020951004.1  methylenetetrahydrofolate reductase isoform X4

    UniProtKB/TrEMBL
    A0A8D0YSM6, A0A8D1YN60
    Conserved Domains (1) summary
    cl00246
    Location:59 → 663
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  7. XM_021095343.1 → XP_020951002.1  methylenetetrahydrofolate reductase isoform X2

    UniProtKB/TrEMBL
    A0A8D1R6C5, K9IVF1
    Conserved Domains (1) summary
    cl00246
    Location:99 → 703
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  8. XM_021095342.1 → XP_020951001.1  methylenetetrahydrofolate reductase isoform X1

    UniProtKB/TrEMBL
    A0A8D1R6C5, K9IVF1
    Conserved Domains (1) summary
    cl00246
    Location:100 → 704
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  9. XM_003127575.4 → XP_003127623.1  methylenetetrahydrofolate reductase isoform X3

    UniProtKB/TrEMBL
    A0A287B634, A0A8D1R6C5, A0A8D1YQU9, K9IVF1
    Related
    ENSSSCP00000051768.2, ENSSSCT00000042716.3
    Conserved Domains (1) summary
    cl00246
    Location:100 → 666
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

RNA

  1. XR_002344905.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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