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ARG1 arginase 1 [ Sus scrofa (pig) ]

Gene ID: 397115, updated on 17-Aug-2024

Summary

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Official Symbol
ARG1provided by VGNC
Official Full Name
arginase 1provided by VGNC
Primary source
VGNC:VGNC:85454
See related
Ensembl:ENSSSCG00000004195
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Biased expression in liver (RPKM 272.4) and mixtures (RPKM 100.6) See more
Orthologs
human mouse all
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Genomic context

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See ARG1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (32006035..32028983, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 1 NC_010443.4 (35580471..35603458, complement)

Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 3 Neighboring gene dihydrofolate reductase-like Neighboring gene mediator complex subunit 23 Neighboring gene uncharacterized LOC106508846 Neighboring gene uncharacterized LOC106508847 Neighboring gene A-kinase anchoring protein 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Proteome Analysis in PAM Cells Reveals That African Swine Fever Virus Can Regulate the Level of Intracellular Polyamines to Facilitate Its Own Replication through ARG1. Ai Q, et al. Viruses, 2021 Jun 26. PMID 34206713, Free PMC Article
  2. A liver-derived immunosuppressive factor is an arginase: identification and mechanism of immunosuppression. Ohtani Y, et al. Biomed Res, 2007 Feb. PMID 17379953
  3. Characterization of a preclinical model of chronic ischemic wound. Roy S, et al. Physiol Genomics, 2009 May 13. PMID 19293328, Free PMC Article
  4. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
  5. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proteome Analysis in PAM Cells Reveals That African Swine Fever Virus Can Regulate the Level of Intracellular Polyamines to Facilitate Its Own Replication through ARG1.
    Title: Proteome Analysis in PAM Cells Reveals That African Swine Fever Virus Can Regulate the Level of Intracellular Polyamines to Facilitate Its Own Replication through ARG1.
  2. Results show that ischemia markedly potentiated the expression of arginase-1, and also induced the SOD2 in the wound tissue.
    Title: Characterization of a preclinical model of chronic ischemic wound.
  3. The immunosuppressive effect of a purified substance (ISF) in the culture medium of neonatal pig liver fragments was due to arginase activity that decreased arginine concentration in culture medium, not to another function of ISF.
    Title: A liver-derived immunosuppressive factor is an arginase: identification and mechanism of immunosuppression.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables arginase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in arginine catabolic process to ornithine IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
arginase-1
Names
arginase I
arginase, liver
liver-type arginase
type I arginase
NP_999213.1
XP_005659247.1
XP_020938398.1
XP_020938404.1
XP_020938406.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214048.2 → NP_999213.1  arginase-1

    See identical proteins and their annotated locations for NP_999213.1

    Status: PROVISIONAL

    Source sequence(s)
    AY039112
    UniProtKB/Swiss-Prot
    Q95JC8
    UniProtKB/TrEMBL
    A0A480QN87, A0A8D1LX53
    Conserved Domains (1) summary
    cd11587
    Location:9 → 303
    Arginase-like; Arginase types I and II and arginase-like family

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

    Range
    32006035..32028983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021082747.1 → XP_020938406.1  arginase-1 isoform X1

    UniProtKB/Swiss-Prot
    Q95JC8
    UniProtKB/TrEMBL
    A0A480QN87, A0A8D1LX53
    Related
    ENSSSCP00000029011.3, ENSSSCT00000035404.4
    Conserved Domains (1) summary
    cd11587
    Location:9 → 303
    Arginase-like; Arginase types I and II and arginase-like family

  2. XM_005659190.2 → XP_005659247.1  arginase-1 isoform X1

    See identical proteins and their annotated locations for XP_005659247.1

    UniProtKB/Swiss-Prot
    Q95JC8
    UniProtKB/TrEMBL
    A0A480QN87, A0A8D1LX53
    Conserved Domains (1) summary
    cd11587
    Location:9 → 303
    Arginase-like; Arginase types I and II and arginase-like family

  3. XM_021082739.1 → XP_020938398.1  arginase-1 isoform X1

    UniProtKB/Swiss-Prot
    Q95JC8
    UniProtKB/TrEMBL
    A0A480QN87, A0A8D1LX53
    Related
    ENSSSCP00000004530.2, ENSSSCT00000004636.5
    Conserved Domains (1) summary
    cd11587
    Location:9 → 303
    Arginase-like; Arginase types I and II and arginase-like family

  4. XM_021082745.1 → XP_020938404.1  arginase-1 isoform X1

    UniProtKB/Swiss-Prot
    Q95JC8
    UniProtKB/TrEMBL
    A0A480QN87, A0A8D1LX53
    Conserved Domains (1) summary
    cd11587
    Location:9 → 303
    Arginase-like; Arginase types I and II and arginase-like family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95JC8.1 GenPept UniProtKB/Swiss-Prot:Q95JC8

Gene LinkOut

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