DHRS4 dehydrogenase/reductase (SDR family) member 4 [Sus scrofa (pig)] - Gene

Summary

Gene symbol: DHRS4
Gene description: dehydrogenase/reductase (SDR family) member 4
See related: Ensembl:ENSSSCG00000002013
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: PSCD; PerCR
Expression: Broad expression in heart (RPKM 398.8), liver (RPKM 295.0) and 6 other tissues See more
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Genomic context

Location:: chromosome: 7

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	7	NC_010449.5 (75242121..75255594, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	7	NC_010449.4 (80512359..80525829, complement)

Chromosome 7 - NC_010449.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studied the association of postmortem pH with SNPs in the fourth member of the short-chain dehydrogenase/reductase family (DHRS4), the first member of serpin peptidase inhibitor, clade G (complement inhibitor) (SERPING1), and the apolipoprotein R precursor (APOR) genes in Berkshire pigs. Results suggest that DHRS4, SERPING1, and APOR snps may be potential genetic markers for meat quality.
Title: Associations of the Polymorphisms in DHRS4, SERPING1, and APOR Genes with Postmortem pH in Berkshire Pigs.
Sus scrofa DHRS4 gene is ortholog of human DHRS4 gene. These two genes have identical splicing phases, exon-intron structure and their coded proteins have identical catalytic amino-acid residues, Rossman fold consensus, Peroxisomal Targeting Signal consensus and the three amino-acid residues typical of vertebrate DHRS4 enzymes
Title: Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.
Peroxisomal localization of tetrameric carbonyl reductase.
Title: Molecular basis for peroxisomal localization of tetrameric carbonyl reductase.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables carbonyl reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in retinal metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in peroxisome	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: dehydrogenase/reductase SDR family member 4

Names: CR; NADPH-dependent carbonyl reductase; NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase; NDRD; PHCR; carbonyl reductase/NADP-retinol dehydrogenase; peroxisomal carbonyl reductase; peroxisomal short-chain alcohol dehydrogenase; short chain dehydrogenase/reductase family 25C member 2

NP_999184.2

EC 1.1.1.184

EC 1.1.1.300

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214019.2 → NP_999184.2 dehydrogenase/reductase SDR family member 4

See identical proteins and their annotated locations for NP_999184.2

Status: VALIDATED

Source sequence(s)

AK234231, AK238514, CJ035044, DB808475

UniProtKB/Swiss-Prot

Q8WNV7

UniProtKB/TrEMBL

A0A480VYS5, A0A8D1GC19

Related

ENSSSCP00000033860.1, ENSSSCT00000043526.3

Conserved Domains (2) summary

cd08936
Location:24 → 279

CR_SDR_c; Porcine peroxisomal carbonyl reductase like, classical (c) SDR

PRK07231
Location:31 → 274

fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional