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IGFBP2 insulin like growth factor binding protein 2 [ Sus scrofa (pig) ]

Gene ID: 397064, updated on 17-Aug-2024

Summary

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Official Symbol
IGFBP2provided by VGNC
Official Full Name
insulin like growth factor binding protein 2provided by VGNC
Primary source
VGNC:VGNC:109491
See related
Ensembl:ENSSSCG00000035392
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
pIGFBP-2
Expression
Biased expression in liver (RPKM 397.2), ovary (RPKM 168.5) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See IGFBP2 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
4
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 15 NC_010457.5 (118822092..118850985)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) Unplaced Scaffold NW_003613137.1 (45713..68476, complement)

Chromosome 15 - NC_010457.5Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37a Neighboring gene uncharacterized LOC110257175 Neighboring gene insulin like growth factor binding protein 5 Neighboring gene transition protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Chromosome location and association of haplotypes of insulin-like growth factor binding protein-2 with production performance in swine. Wang W, et al. Biochem Genet, 2008 Aug. PMID 18427978
  2. Complex mediation of uterine endometrial epithelial cell growth by insulin-like growth factor-II (IGF-II) and IGF-binding protein-2. Badinga L, et al. J Mol Endocrinol, 1999 Dec. PMID 10601973
  3. The unique endometrial expression and genomic organization of the porcine IGFBP-2 gene. Song S, et al. Mol Cell Endocrinol, 1996 Jul 1. PMID 8832579
  4. Identification and NH2-terminal amino acid sequence of three insulin-like growth factor-binding proteins in porcine serum. Coleman ME, et al. Biochem Biophys Res Commun, 1991 Dec 31. PMID 1722398
  5. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest that IGFBP-2 is associated with production performance in pigs.
    Title: Chromosome location and association of haplotypes of insulin-like growth factor binding protein-2 with production performance in swine.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables insulin-like growth factor I binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin-like growth factor II binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin-like growth factor-binding protein 2
Names
IBP-2
IGF-binding protein 2
IGFBP-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214003.1 → NP_999168.1  insulin-like growth factor-binding protein 2 precursor

    See identical proteins and their annotated locations for NP_999168.1

    Status: PROVISIONAL

    Source sequence(s)
    AF120326
    UniProtKB/Swiss-Prot
    P24853, Q9XSC7
    UniProtKB/TrEMBL
    E3W6T5
    Related
    ENSSSCP00000058079.1, ENSSSCT00000046489.2
    Conserved Domains (2) summary
    smart00121
    Location:33 → 124
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:218 → 297
    Thyroglobulin_1; Thyroglobulin type-1 repeat

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010457.5 Reference Sscrofa11.1 Primary Assembly

    Range
    118822092..118850985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24853.2 GenPept UniProtKB/Swiss-Prot:P24853

Gene LinkOut

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