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CYP27B1 cytochrome P450 family 27 subfamily B member 1 [ Sus scrofa (pig) ]

Gene ID: 397055, updated on 17-Aug-2024

Summary

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Official Symbol
CYP27B1provided by VGNC
Official Full Name
cytochrome P450 family 27 subfamily B member 1provided by VGNC
Primary source
VGNC:VGNC:103376
See related
Ensembl:ENSSSCG00000028637
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Biased expression in kidney (RPKM 13.0), mixtures (RPKM 2.4) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See CYP27B1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 5 NC_010447.5 (23053129..23058865, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) Unplaced Scaffold NW_003537551.1 (17074..22049)

Chromosome 5 - NC_010447.5Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 4 Neighboring gene membrane associated ring-CH-type finger 9 Neighboring gene methyltransferase 1, tRNA methylguanosine Neighboring gene EEF1A lysine methyltransferase 3 Neighboring gene Ts translation elongation factor, mitochondrial

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Cloning of porcine 25-hydroxyvitamin D3 1alpha-hydroxylase and its regulation by cAMP in LLC-PK1 cells. Yoshida T, et al. J Am Soc Nephrol, 1999 May. PMID 10232681
  2. Calcitonin, a regulator of the 25-hydroxyvitamin D3 1alpha-hydroxylase gene. Zhong Y, et al. J Biol Chem, 2009 Apr 24. PMID 19261615, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Calcitonin is a regulator of the 25-hydroxyvitamin D3 1alpha-hydroxylase gene
    Title: Calcitonin, a regulator of the 25-hydroxyvitamin D3 1alpha-hydroxylase gene.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in C21-steroid hormone biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to peptide hormone stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cortisol metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glucocorticoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Names
25-hydroxyvitamin D3 1alpha-hydroxylase
NP_999160.1
XP_020946783.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213995.1 → NP_999160.1  25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

    See identical proteins and their annotated locations for NP_999160.1

    Status: PROVISIONAL

    Source sequence(s)
    AB018743
    UniProtKB/TrEMBL
    A0A4X1W5C0, A0A8D0MYN7, A0A8D0R998, A0A8D1FA75, I3LDM2, Q9XS57
    Related
    ENSSSCP00000022154.3, ENSSSCT00000023069.4
    Conserved Domains (1) summary
    pfam00067
    Location:37 → 501
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010447.5 Reference Sscrofa11.1 Primary Assembly

    Range
    23053129..23058865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021091124.1 → XP_020946783.1  25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    I3LDM2
    Conserved Domains (1) summary
    pfam00067
    Location:37 → 462
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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