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MDH2 malate dehydrogenase 2 [ Sus scrofa (pig) ]

Gene ID: 397039, updated on 17-Aug-2024

Summary

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Official Symbol
MDH2provided by VGNC
Official Full Name
malate dehydrogenase 2provided by VGNC
Primary source
VGNC:VGNC:110289
See related
Ensembl:ENSSSCG00000025486
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
MDH; MMDH
Expression
Broad expression in heart (RPKM 623.2), psoas major muscle (RPKM 438.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See MDH2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 3 NC_010445.4 (10120121..10132705, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 3 NC_010445.3 (9953279..9965866, complement)

Chromosome 3 - NC_010445.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110259893 Neighboring gene serine/arginine repetitive matrix 3 Neighboring gene serine/threonine/tyrosine interacting like 1 Neighboring gene transmembrane protein 120A Neighboring gene cytochrome p450 oxidoreductase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Macromolecular crowding and the steady-state kinetics of malate dehydrogenase. Poggi CG, et al. Biochemistry, 2015 Jan 20. PMID 25478785
  2. Amino acid sequence homology among the 2-hydroxy acid dehydrogenases: mitochondrial and cytoplasmic malate dehydrogenases form a homologous system with lactate dehydrogenase. Birktoft JJ, et al. Proc Natl Acad Sci U S A, 1982 Oct. PMID 6959107, Free PMC Article
  3. Substrate binding site flexibility of the small heat shock protein molecular chaperones. Jaya N, et al. Proc Natl Acad Sci U S A, 2009 Sep 15. PMID 19717454, Free PMC Article
  4. Refined crystal structure of mitochondrial malate dehydrogenase from porcine heart and the consensus structure for dicarboxylic acid oxidoreductases. Gleason WB, et al. Biochemistry, 1994 Mar 1. PMID 8117664
  5. Cloning and sequence analysis of cDNAs encoding mammalian mitochondrial malate dehydrogenase. Joh T, et al. Biochemistry, 1987 May 5. PMID 3038184

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables L-malate dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in malate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
malate dehydrogenase, mitochondrial
Names
malate dehydrogenase 2, NAD (mitochondrial)
mitochondrial malate dehydrogenase 2, NAD
NP_001231082.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001244153.1 → NP_001231082.1  malate dehydrogenase, mitochondrial

    Status: PROVISIONAL

    Source sequence(s)
    AK232730
    UniProtKB/TrEMBL
    A0A480KJB8, A0A4X1UJD6, A0A5G2RGL7
    Related
    ENSSSCP00000070379.2, ENSSSCT00000080030.2
    Conserved Domains (2) summary
    TIGR01772
    Location:26 → 335
    MDH_euk_gproteo; malate dehydrogenase, NAD-dependent
    cd01337
    Location:26 → 334
    MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010445.4 Reference Sscrofa11.1 Primary Assembly

    Range
    10120121..10132705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00346.2 GenPept UniProtKB/Swiss-Prot:P00346

Gene LinkOut

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