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B2M beta-2-microglobulin [ Sus scrofa (pig) ]

Gene ID: 397033, updated on 16-Nov-2023

Summary

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Gene symbol
B2M
Gene description
beta-2-microglobulin
See related
Ensembl:ENSSSCG00000051899
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Annotation information
Annotation category: partial on reference assembly
Expression
Ubiquitous expression in spleen (RPKM 5169.6), lung (RPKM 4618.3) and 8 other tissues See more
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Genomic context

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See B2M in Genome Data Viewer
Location:
chromosome: 1
Exon count:
5
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (126865767..126878501, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 1 NC_010443.4 (141437043..141449779, complement)

Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110261204 Neighboring gene beta-2-microglobulin Neighboring gene uncharacterized LOC110261210 Neighboring gene SPG11 vesicle trafficking associated, spatacsin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. [Analyzing secondary structure of beta2 microglobulin in Escherichia coli with circular dichroism spectrum]. Gao F, et al. Wei Sheng Wu Xue Bao, 2009 Dec. PMID 20222444
  2. Isolation of a clone for pig beta 2-microglobulin cDNA. Milland J, et al. Immunogenetics, 1993. PMID 8406623
  3. Development of a new set of reference genes for normalization of real-time RT-PCR data of porcine backfat and longissimus dorsi muscle, and evaluation with PPARGC1A. Erkens T, et al. BMC Biotechnol, 2006 Oct 9. PMID 17026777, Free PMC Article
  4. Selection of reference genes for gene expression studies in pig tissues using SYBR green qPCR. Nygard AB, et al. BMC Mol Biol, 2007 Aug 15. PMID 17697375, Free PMC Article
  5. Evaluation and characterization of a porcine small intestine cDNA library: analysis of 839 clones. Wintero AK, et al. Mamm Genome, 1996 Jul. PMID 8672129

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. B2M contains alpha-helix, beta-sheet, turn, and random coil.
    Title: [Analyzing secondary structure of beta2 microglobulin in Escherichia coli with circular dichroism spectrum].
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables MHC class II protein complex binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptide antigen assembly with MHC class II protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of MHC class I protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of MHC class II protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
beta-2-microglobulin
Names
lactollin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213978.1 → NP_999143.1  beta-2-microglobulin precursor

    See identical proteins and their annotated locations for NP_999143.1

    Status: PROVISIONAL

    Source sequence(s)
    L13854
    UniProtKB/Swiss-Prot
    Q07717, Q8WN08
    UniProtKB/TrEMBL
    A0A5S6FYV9, B2NJ26
    Related
    ENSSSCP00000063329.1, ENSSSCT00000084189.2
    Conserved Domains (1) summary
    cd05770
    Location:24 → 115
    IgC_beta2m; Class I major histocompatibility complex (MHC) beta2-microglobulin

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

    Range
    126865767..126878501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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