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ANGPT1 angiopoietin 1 [ Sus scrofa (pig) ]

Gene ID: 397009, updated on 17-Aug-2024

Summary

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Official Symbol
ANGPT1provided by VGNC
Official Full Name
angiopoietin 1provided by VGNC
Primary source
VGNC:VGNC:98732
See related
Ensembl:ENSSSCG00000006035
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
AGPT
Expression
Broad expression in lung (RPKM 5.8), kidney (RPKM 2.1) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See ANGPT1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 4 NC_010446.5 (29925203..30233434)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 4 NC_010446.4 (32433135..32433409) , (32646874..32751649) , (32833909..32855132)

Chromosome 4 - NC_010446.5Genomic Context describing neighboring genes Neighboring gene R-spondin 2 Neighboring gene ferritin light chain pseudogene Neighboring gene uncharacterized LOC110260240 Neighboring gene uncharacterized LOC106510002

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Microvascular network remodeling in dura mater of ovariectomized pigs: role for angiopoietin-1 in estrogen-dependent control of vascular stability. Glinskii OV, et al. Am J Physiol Heart Circ Physiol, 2007 Aug. PMID 17496211, Free PMC Article
  2. Immunohistochemical detection of the angiopoietins during porcine metanephric kidney development. De Spiegelaere W, et al. Acta Histochem, 2011 Sep. PMID 20598355
  3. Angiopoietin-1 attenuates H2O2-induced SEK1/JNK phosphorylation through the phosphatidylinositol 3-kinase/Akt pathway in vascular endothelial cells. Murakami T, et al. J Biol Chem, 2005 Sep 9. PMID 16000309
  4. Immunohistochemical determination of Ang-1, Ang-2 and Tie-2 in placentas of sows at 30, 60 and 114 days of gestation and validation through a bioinformatic approach. Fiorimanti MR, et al. Anim Reprod Sci, 2018 Aug. PMID 29885854
  5. The angiopoietin-tie2 system in coronary artery endothelium prevents oxidized low-density lipoprotein-induced apoptosis. Kim I, et al. Cardiovasc Res, 2001 Mar. PMID 11230987

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The presence of angiopoietins in the trophoblast suggests a specific role for these pro-angiogenic factors in the tissue formation at the maternal-fetal interface.
    Title: Immunohistochemical determination of Ang-1, Ang-2 and Tie-2 in placentas of sows at 30, 60 and 114 days of gestation and validation through a bioinformatic approach.
  2. Angiopoietin 1 was predominantly present in the maturing glomeruli.
    Title: Immunohistochemical detection of the angiopoietins during porcine metanephric kidney development.
  3. The expression of ANGPT1 has already been studied during metanephric glomerulogenesis, but it remains to be elucidated during the development of the embryonic mesonephros.
    Title: Expression and localization of angiogenic growth factors in developing porcine mesonephric glomeruli.
  4. Estrogen-dependent control of Ang-1 expression plays an important role in stabilizing meningeal microvessel and maintaining healthy microvascular networks.
    Title: Microvascular network remodeling in dura mater of ovariectomized pigs: role for angiopoietin-1 in estrogen-dependent control of vascular stability.
  5. Attenuates H2O2-induced stress-activated protein kinase (SEK)1/JNK phosphorylation through the PI 3-kinase/Akt pathway and inhibits the apoptosis of vascular endothelial cells induced by oxidative stress.
    Title: Angiopoietin-1 attenuates H2O2-induced SEK1/JNK phosphorylation through the phosphatidylinositol 3-kinase/Akt pathway in vascular endothelial cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Tie signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
angiopoietin-1
Names
ANG-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213959.1 → NP_999124.1  angiopoietin-1 precursor

    See identical proteins and their annotated locations for NP_999124.1

    Status: PROVISIONAL

    Source sequence(s)
    AF233227
    UniProtKB/Swiss-Prot
    Q9BDY8
    UniProtKB/TrEMBL
    A0A8D0MJG5
    Conserved Domains (2) summary
    cd00087
    Location:281 → 496
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    cl23763
    Location:68 → 264
    MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010446.5 Reference Sscrofa11.1 Primary Assembly

    Range
    29925203..30233434
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021088688.1 → XP_020944347.1  angiopoietin-1 isoform X5

    UniProtKB/TrEMBL
    A0A5G2RBC7
    Related
    ENSSSCP00000074317.2, ENSSSCT00000075145.2
    Conserved Domains (2) summary
    cd00087
    Location:192 → 407
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    cl25732
    Location:16 → 203
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_021088686.1 → XP_020944345.1  angiopoietin-1 isoform X3

    UniProtKB/TrEMBL
    A0A4X1TH61, A0A8D0IEF6, A0A8D0MJG5, F1S1F8
    Related
    ENSSSCP00000006448.4, ENSSSCT00000006624.5
    Conserved Domains (2) summary
    cd00087
    Location:280 → 495
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    cl25732
    Location:81 → 256
    SMC_N; RecF/RecN/SMC N terminal domain

  3. XM_021088684.1 → XP_020944343.1  angiopoietin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8D0MJG5
    Conserved Domains (2) summary
    cd00087
    Location:289 → 504
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    cl25732
    Location:113 → 266
    SMC_N; RecF/RecN/SMC N terminal domain

  4. XM_021088685.1 → XP_020944344.1  angiopoietin-1 isoform X2

    UniProtKB/TrEMBL
    A0A8D0MJG5
    Conserved Domains (2) summary
    cd00087
    Location:288 → 503
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    cl25732
    Location:113 → 266
    SMC_N; RecF/RecN/SMC N terminal domain

  5. XM_021088687.1 → XP_020944346.1  angiopoietin-1 isoform X4

    UniProtKB/TrEMBL
    A0A5G2RBC7
    Conserved Domains (2) summary
    cd00087
    Location:193 → 408
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    cl25732
    Location:17 → 204
    SMC_N; RecF/RecN/SMC N terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BDY8.1 GenPept UniProtKB/Swiss-Prot:Q9BDY8

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Research Materials