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TIMP2 TIMP metallopeptidase inhibitor 2 [ Sus scrofa (pig) ]

Gene ID: 396988, updated on 17-Aug-2024

Summary

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Official Symbol
TIMP2provided by VGNC
Official Full Name
TIMP metallopeptidase inhibitor 2provided by VGNC
Primary source
VGNC:VGNC:93995
See related
Ensembl:ENSSSCG00000017164
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
TIMP-2
Expression
Broad expression in subcutaneous adipose (RPKM 97.2), ovary (RPKM 74.2) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See TIMP2 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 12 NC_010454.4 (3254794..3300835)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 12 NC_010454.3 (3294254..3340447)

Chromosome 12 - NC_010454.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110255950 Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene CEP295 N-terminal like Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene ubiquitin specific peptidase 36 Neighboring gene cytohesin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Molecular, histologic, and gross phenotype of skin wound healing in red Duroc pigs reveals an abnormal healing phenotype of hypercontracted, hyperpigmented scarring. Gallant CL, et al. Wound Repair Regen, 2004 May-Jun. PMID 15225209
  2. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protease binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
metalloproteinase inhibitor 2
Names
tissue inhibitor of metalloproteinase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145985.1 → NP_001139457.1  metalloproteinase inhibitor 2 precursor

    See identical proteins and their annotated locations for NP_001139457.1

    Status: PROVISIONAL

    Source sequence(s)
    FJ394384
    UniProtKB/TrEMBL
    A0A4X1UID2, A0A8D0K0M0, C0JPM4
    Related
    ENSSSCP00000018187.2, ENSSSCT00000018688.4
    Conserved Domains (1) summary
    cd03585
    Location:28 → 210
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010454.4 Reference Sscrofa11.1 Primary Assembly

    Range
    3254794..3300835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_013989846.2 → XP_013845300.1  metalloproteinase inhibitor 2 isoform X3

    UniProtKB/TrEMBL
    A0A5G2QTA4, A0A8D0SPT3
    Related
    ENSSSCP00000068156.1, ENSSSCT00000072140.2
    Conserved Domains (1) summary
    cd03585
    Location:8 → 172
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

  2. XM_021066201.1 → XP_020921860.1  metalloproteinase inhibitor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8D1ILR1
    Conserved Domains (1) summary
    cd03585
    Location:56 → 233
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

  3. XM_021066202.1 → XP_020921861.1  metalloproteinase inhibitor 2 isoform X2

    UniProtKB/TrEMBL
    A0A5G2QC50, A0A5G2QTA4, A0A5G2R175, A0A8D0SPT3
    Related
    ENSSSCP00000064262.2, ENSSSCT00000086368.2
    Conserved Domains (1) summary
    cd03585
    Location:39 → 205
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...
Nucleotide Protein
Heading Accession and Version

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