PLAU plasminogen activator, urokinase [Sus scrofa (pig)] - Gene

Summary

Official Symbol: PLAUprovided by VGNC
Official Full Name: plasminogen activator, urokinaseprovided by VGNC
Primary source: VGNC:VGNC:91511
See related: Ensembl:ENSSSCG00000010312
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: uPA
Expression: Ubiquitous expression in lung (RPKM 13.0), subcutaneous adipose (RPKM 11.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	14	NC_010456.5 (76629313..76635173)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	14	NC_010456.4 (82755642..82761502)

Chromosome 14 - NC_010456.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The plasminogen/plasminogen activator/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte.
Title: Fertilization outcome could be regulated by binding of oviductal plasminogen to oocytes and by releasing of plasminogen activators during interplay between gametes.

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General gene information

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Markers

PLAU (e-PCR), detects polymorphism
- UniSTS:266574

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in fibrinolysis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in plasminogen activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: urokinase-type plasminogen activator

Names: U-plasminogen activator; urinary plasminogen activator

NP_999110.1

EC 3.4.21.73

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213945.1 → NP_999110.1 urokinase-type plasminogen activator precursor

See identical proteins and their annotated locations for NP_999110.1

Status: PROVISIONAL

Source sequence(s)

X02724

UniProtKB/Swiss-Prot

P04185

UniProtKB/TrEMBL

A0A8D0U9D8

Related

ENSSSCP00000010995.2, ENSSSCT00000011287.4

Conserved Domains (3) summary

smart00020
Location:189 → 430

Tryp_SPc; Trypsin-like serine protease

smart00130
Location:70 → 155

KR; Kringle domain

cd00190
Location:190 → 433

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...