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APEH acylaminoacyl-peptide hydrolase [ Sus scrofa (pig) ]

Gene ID: 396961, updated on 17-Aug-2024

Summary

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Official Symbol
APEHprovided by VGNC
Official Full Name
acylaminoacyl-peptide hydrolaseprovided by VGNC
Primary source
VGNC:VGNC:85408
See related
Ensembl:ENSSSCG00000011385
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
AAP; APH; AARE
Expression
Ubiquitous expression in ovary (RPKM 21.2), kidney (RPKM 20.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See APEH in Genome Data Viewer
Location:
chromosome: 13
Exon count:
22
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 13 NC_010455.5 (32205863..32214517)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 13 NC_010455.4 (35385067..35393717)

Chromosome 13 - NC_010455.5Genomic Context describing neighboring genes Neighboring gene dystroglycan 1 Neighboring gene tumor suppressor candidate 2-like Neighboring gene bassoon presynaptic cytomatrix protein Neighboring gene ring finger protein 123 Neighboring gene macrophage stimulating 1 Neighboring gene GDP-mannose pyrophosphorylase B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Crystallization and preliminary crystallographic analysis of porcine acylaminoacyl peptidase. Wright H, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2005 Oct 1. PMID 16511202, Free PMC Article
  2. His507 of acylaminoacyl peptidase stabilizes the active site conformation, not the catalytic intermediate. Kiss AL, et al. FEBS Lett, 2004 Jul 30. PMID 15280010
  3. Structural properties of porcine intestine acylpeptide hydrolase. Durand A, et al. J Protein Chem, 2003 Feb. PMID 12760423
  4. Distribution and subcellular localization of acylpeptide hydrolase and acylase I along the hog gastro-intestinal tract. Giardina T, et al. Biochimie, 1999 Nov. PMID 10575361
  5. Complete covalent structure of porcine liver acylamino acid-releasing enzyme and identification of its active site serine residue. Miyagi M, et al. J Biochem, 1995 Oct. PMID 8576092

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. crystallographic analysis of porcine acylaminoacyl peptidase
    Title: Crystallization and preliminary crystallographic analysis of porcine acylaminoacyl peptidase.
  2. His507 is an important residue that is probably involved in the formation of the 3-dimensional structure (acylaminoacyl peptidase)
    Title: His507 of acylaminoacyl peptidase stabilizes the active site conformation, not the catalytic intermediate.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
acylamino-acid-releasing enzyme
Names
N-acylaminoacyl-peptide hydrolase
N-acylpeptide hydrolase
acyl-peptide hydrolase
acylaminoacyl peptidase
NP_999088.1
XP_005669617.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213923.1 → NP_999088.1  acylamino-acid-releasing enzyme

    See identical proteins and their annotated locations for NP_999088.1

    Status: PROVISIONAL

    Source sequence(s)
    D00524
    UniProtKB/Swiss-Prot
    P19205, Q9TS46
    UniProtKB/TrEMBL
    A0A480JIF5
    Related
    ENSSSCP00000012138.3, ENSSSCT00000012463.5
    Conserved Domains (2) summary
    COG1506
    Location:157 → 732
    DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
    cl21494
    Location:510 → 732
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010455.5 Reference Sscrofa11.1 Primary Assembly

    Range
    32205863..32214517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005669560.2 → XP_005669617.1  acylamino-acid-releasing enzyme isoform X1

    UniProtKB/TrEMBL
    A0A4X1ST38
    Conserved Domains (2) summary
    pfam12697
    Location:402 → 610
    Abhydrolase_6; Alpha/beta hydrolase family
    cl21494
    Location:409 → 631
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19205.2 GenPept UniProtKB/Swiss-Prot:P19205

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials