HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: HSD11B2provided by VGNC
Official Full Name: hydroxysteroid 11-beta dehydrogenase 2provided by VGNC
Primary source: VGNC:VGNC:88985
See related: Ensembl:ENSSSCG00000002777
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Biased expression in kidney (RPKM 87.8), mixtures (RPKM 15.5) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	6	NC_010448.4 (28084087..28089256)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	6	NC_010448.3 (25351178..25356346)

Chromosome 6 - NC_010448.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that the effects of maternal protein restriction on placental 11beta-HSD2 expression are gender-dependent in the pig, and thyroid hormones may be involved in such effects.
Title: Sexually dimorphic effects of maternal dietary protein restriction on fetal growth and placental expression of 11β-HSD2 in the pig.
Postnatal ontogeny of 11beta-HSD2 gene expression is described for the first time in stress-related brain regions of domestic pigs at 7, 21, and 35 days of age.
Title: Age-related changes in corticosteroid receptor expression and monoamine neurotransmitter concentrations in various brain regions of postnatal pigs.
Data show that in the testis, caput epididymidis and bulbourethral gland of the immature pig, 11betaHSD1 and 2 catalyse inactivation of cortisol, supporting a role in limiting local actions of glucocorticoids within these tissues prior to puberty.
Title: Expression and activities of 11betaHSD enzymes in the testes and reproductive tracts of sexually immature male pigs.
The amount of 11beta-HSD 2 in germ cells was greatest at birth, decreased thereafter and was absent after Week 3.
Title: Aromatase and 11beta-hydroxysteroid dehydrogenase 2 localisation in the testes of pigs from birth to puberty linked to changes of hormone pattern and testicular morphology.
11beta-HSD type 2, which is abundantly expressed, plays important roles in cortisol inactivation in pig Leydig cells.
Title: Leydig cells from neonatal pig testis abundantly express 11beta-hydroxysteroid dehydrogenase (11beta-HSD) type 2 and effectively inactivate cortisol to cortisone.
The expression of 11beta-HSD2 in several types of cells forms consecutive lines of defense may protect spermatogonia against glucocorticoid-induced apoptosis.
Title: Expression of 11beta-hydroxysteroid-dehydrogenase 2 in Sertoli cells of boar testes.
concluded that the 11beta-hydroxysteroid dehydrogenase (11beta-HSD1 and 2) system is involved in the regulation of cortisol activity in the testis and thus in the regulation of spermatogenesis
Title: Characterization of 11beta-hydroxysteroid dehydrogenase activity in testicular tissue of control and GnRH-immunized boars as a possible regulator of spermatogenesis.
Effects of age, weaning and/or social isolation on the expression of genes regulating HSD11B2.
Title: Effects of early weaning and social isolation on the expression of glucocorticoid and mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase 1 and 2 mRNAs in the frontal cortex and hippocampus of piglets.

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General gene information

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Markers

MARC_2785-2786:991933423:1 (e-PCR)
- UniSTS:230950

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 11-beta-hydroxysteroid dehydrogenase type 2

Names: 11-beta hydroxysteroid dehydrogenase

NP_999078.1

EC 1.1.1.146

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213913.1 → NP_999078.1 11-beta-hydroxysteroid dehydrogenase type 2

See identical proteins and their annotated locations for NP_999078.1

Status: PROVISIONAL

Source sequence(s)

AF374414

UniProtKB/TrEMBL

A0A8D0QC78, A0A8D1XZD2, Q8MKG1

Related

ENSSSCP00000002996.2, ENSSSCT00000003075.4

Conserved Domains (2) summary

cd09805
Location:83 → 363

type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

pfam00106
Location:83 → 277

adh_short; short chain dehydrogenase