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CG7656 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39691, updated on 2-Nov-2024

Summary

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Official Symbol
CG7656provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036516
Locus tag
Dmel_CG7656
See related
AllianceGenome:FB:FBgn0036516
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG7656
Summary
Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein K48-linked ubiquitination and ubiquitin-dependent protein catabolic process. Is expressed in central brain primordium; embryonic brain; organism; and ventral nerve cord primordium. Orthologous to human CDC34 (cell division cycle 34, ubiqiutin conjugating enzyme) and UBE2R2 (ubiquitin conjugating enzyme E2 R2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See CG7656 in Genome Data Viewer
Location:
71E1-71E1; 3-43 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15585431..15588175, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15578531..15581275, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene aaRS-interacting multifunctional protein 2 Neighboring gene Rho GTPase activating protein at 71E Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of factors that function in Drosophila salivary gland cell death during development using proteomics. McPhee CK, et al. Cell Death Differ, 2013 Feb. PMID 22935612, Free PMC Article
  2. Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins. Jones D, et al. Genome Biol, 2002. PMID 11806825, Free PMC Article
  3. What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor? Michelle C, et al. J Mol Evol, 2009 Jun. PMID 19452197, Free PMC Article
  4. A novel strategy to isolate ubiquitin conjugates reveals wide role for ubiquitination during neural development. Franco M, et al. Mol Cell Proteomics, 2011 May. PMID 20861518, Free PMC Article
  5. The BEAF insulator regulates genes involved in cell polarity and neoplastic growth. Gurudatta BV, et al. Dev Biol, 2012 Sep 1. PMID 22743648, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein K48-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG7656-PA
CG7656-PD
CG7656-PE
CG7656-PF
NP_001261885.1
NP_648783.4
NP_730058.2
NP_730059.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15585431..15588175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274956.1 → NP_001261885.1  uncharacterized protein Dmel_CG7656, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261885.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NN25, Q8IQM5
    Conserved Domains (2) summary
    COG5078
    Location:45 → 182
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:42 → 186
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  2. NM_168628.3 → NP_730059.1  uncharacterized protein Dmel_CG7656, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730059.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NN25, Q8IQM5
    Related
    FBpp0075345
    Conserved Domains (2) summary
    COG5078
    Location:45 → 182
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:42 → 186
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  3. NM_168627.3 → NP_730058.2  uncharacterized protein Dmel_CG7656, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730058.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQC8, Q6NN25, Q8IQM4, Q9VUR4
    Conserved Domains (2) summary
    COG5078
    Location:45 → 182
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:42 → 186
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  4. NM_140526.5 → NP_648783.4  uncharacterized protein Dmel_CG7656, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648783.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQC8, Q6NN25, Q8IQM4, Q9VUR4
    Conserved Domains (2) summary
    COG5078
    Location:45 → 182
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:42 → 186
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AWG5 Q6AWG5
Q8IQM5 Q8IQM5
Q960Q5 Q960Q5
Q9VUR4 Q9VUR4

Gene LinkOut

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