ATP1B1 ATPase Na+/K+ transporting subunit beta 1 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: ATP1B1provided by VGNC
Official Full Name: ATPase Na+/K+ transporting subunit beta 1provided by VGNC
Primary source: VGNC:VGNC:85642
See related: Ensembl:ENSSSCG00000006296
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Broad expression in kidney (RPKM 737.7), mixtures (RPKM 187.0) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	4	NC_010446.5 (81912543..81937015, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	4	NC_010446.4 (89530583..89550423, complement)

Chromosome 4 - NC_010446.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

re-arrangements of the Na+,K+-ATPase stabilized by cardiotonic steroids may affect protein-protein interactions within the intracellular signal transduction networks
Title: Structural insights into the high affinity binding of cardiotonic steroids to the Na+,K+-ATPase.
Na,K-ATPase is a new target of TGF-beta(1)-mediated Epithelial-to-mesenchymal transition in renal epithelial cells, a model system used in studies of both cancer progression and fibrosis.
Title: Na,K-ATPase subunits as markers for epithelial-mesenchymal transition in cancer and fibrosis.
Neutralization of the charge on Asp 369 of Na+,K+-ATPase triggers conformational changes.
Title: Neutralization of the charge on Asp 369 of Na+,K+-ATPase triggers E1 <--> E2 conformational changes.
Propose that kinase-dependent regulation of the Na(+)-K(+) pump occurs via glutathionylation of its beta(1) subunit (ATP1B1) at Cys46.
Title: Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation.

Submit: New GeneRIF Correction

General gene information

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Markers

ATP1B1 (e-PCR)
- UniSTS:253863

ATP1B1 (e-PCR)
- UniSTS:503734

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATPase activator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular potassium ion homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular sodium ion homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in potassium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
involved_in sodium ion export across plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of sodium:potassium-exchanging ATPase complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: sodium/potassium-transporting ATPase subunit beta-1

Names: ATPase, Na+/K+ transporting, beta 1 polypeptide; Na+, K+-ATPase beta-subunit; sodium/potassium-dependent ATPase subunit beta-1

NP_001001542.1

EC 3.6.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.