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RLN2 relaxin 2 [ Sus scrofa (pig) ]

Gene ID: 396891, updated on 16-Nov-2023

Summary

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Gene symbol
RLN2
Gene description
relaxin 2
See related
Ensembl:ENSSSCG00000005216
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
RLN
Expression
Low expression observed in reference dataset See more
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Genomic context

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See RLN2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
3
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (216763546..216769802)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 1 NC_010443.4 (242497113..242503501)

Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene programmed cell death 1 ligand 2 Neighboring gene CD274 molecule Neighboring gene plasminogen receptor with a C-terminal lysine Neighboring gene insulin like 6 Neighboring gene Janus kinase 2 Neighboring gene NEDD8-activating enzyme E1 catalytic subunit pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Milk-borne relaxin and reproductive system development. Bagnell CA, et al. Ital J Anat Embryol, 2013. PMID 24640560
  2. Relaxin protects against renal ischemia-reperfusion injury. Yoshida T, et al. Am J Physiol Renal Physiol, 2013 Oct 15. PMID 23946288
  3. Milk-borne lactocrine-acting factors affect gene expression patterns in the developing neonatal porcine uterus. Chen JC, et al. Reproduction, 2011 May. PMID 21317299
  4. Characterization and biological activity of relaxin in porcine milk. Frankshun AL, et al. Reproduction, 2011 Mar. PMID 21177955
  5. Paracrine effects of transplanted myoblasts and relaxin on post-infarction heart remodelling. Formigli L, et al. J Cell Mol Med, 2007 Sep-Oct. PMID 17979884, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Relaxin serves as a model for understanding lactocrine signals that support development of neonatal tissues.
    Title: Milk-borne relaxin and reproductive system development.
  2. Swine relaxin provides protection against ischemia-reperfusion-induced renal injury in rats by reducing apoptosis and inflammation.
    Title: Relaxin protects against renal ischemia-reperfusion injury.
  3. Establishment of the neonatal porcine uterine developmental program requires maternal lactocrine support via relaxin.
    Title: Milk-borne lactocrine-acting factors affect gene expression patterns in the developing neonatal porcine uterus.
  4. Results support the lactocrine hypothesis by defining the nature and a potential source for bioactive proRLX in porcine colostrum/milk.
    Title: Characterization and biological activity of relaxin in porcine milk.
  5. Relaxin was detected in denuded oocytes, cumulus cells, mature boar spermatozoa, zygotes, and embryos (cleaved and blastocysts).
    Title: Examination of relaxin and its receptors expression in pig gametes and embryos.
  6. Exogenous relaxin influences its own receptors expression, improves oocyte nuclear maturation. Its beneficial effect on total cell number of blastocysts appears to be through a Bcl2-like1/Bax-independent mechanism.
    Title: In vitro effects of relaxin on gene expression in porcine cumulus-oocyte complexes and developing embryos.
  7. This study provides evidence for expression of RLN-RXFP1 ligand-receptor system in the boar testis, suggesting that the testes act as a source and possible target tissue of RLN.
    Title: Evidence for expression of relaxin hormone-receptor system in the boar testis.
  8. Changes of relaxin mRNA are correlated with changes of the hormone in the CL during pregnancy, suggesting that the relaxin level is determined by the amount of mRNA available for translation.
    Title: Expression and cellular pattern of relaxin mRNA in porcine corpora lutea during pregnancy.
  9. Relaxin-producing C2C12 myoblasts displayed greater efficacy to engraft the post-ischaemic scar and to induce extracellular matrix re-modelling and angiogenesis as compared with the control cells
    Title: Paracrine effects of transplanted myoblasts and relaxin on post-infarction heart remodelling.
  10. role on neonatal porcine uterine growth and development
    Title: Effects of relaxin on neonatal porcine uterine growth and development.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
prorelaxin
Names
preprorelaxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213872.1 → NP_999037.1  prorelaxin precursor

    See identical proteins and their annotated locations for NP_999037.1

    Status: PROVISIONAL

    Source sequence(s)
    K01088
    UniProtKB/Swiss-Prot
    P01348
    UniProtKB/TrEMBL
    A0A4X1W973
    Related
    ENSSSCP00000005607.3, ENSSSCT00000005749.4
    Conserved Domains (1) summary
    cd04365
    Location:30 → 182
    IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

    Range
    216763546..216769802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021082276.1 → XP_020937935.1  prorelaxin isoform X1

    Conserved Domains (1) summary
    cd04365
    Location:77 → 111
    IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P01348.1 GenPept UniProtKB/Swiss-Prot:P01348

Gene LinkOut

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