LEP leptin [Sus scrofa (pig)] - Gene

Summary

Official Symbol: LEPprovided by VGNC
Official Full Name: leptinprovided by VGNC
Primary source: VGNC:VGNC:89684
See related: Ensembl:ENSSSCG00000040464
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: OB; OBS
Expression: Restricted expression toward subcutaneous adipose (RPKM 9.4) See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	18	NC_010460.4 (20106867..20124071, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	18	NC_010460.3 (21200988..21231275)

Chromosome 18 - NC_010460.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?
Title: Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?
Evaluation of Fat Accumulation and Adipokine Production during the Long-Term Adipogenic Differentiation of Porcine Intramuscular Preadipocytes and Study of the Influence of Immunobiotics.
Title: Evaluation of Fat Accumulation and Adipokine Production during the Long-Term Adipogenic Differentiation of Porcine Intramuscular Preadipocytes and Study of the Influence of Immunobiotics.
study has allowed a transcriptional characterization of LEP and LEPR isoforms on a range of tissues. Their expression patterns seem to indicate that both molecules develop peripheral roles apart from their known hypothalamic signal transduction function
Title: Transcriptional Characterization of Porcine Leptin and Leptin Receptor Genes.
The lack of effect of heat stress on the expression of leptin suggests that this peptide may not be involved in the reduction of feed intake of HS acclimated pigs.
Title: Effect of heat stress on performance and expression of selected amino acid and glucose transporters, HSP90, leptin and ghrelin in growing pigs.
A high variability of the LEP was detected in the different analysed populations providing new data for the existence of two domestication centres in Asia.
Title: Haplotypic diversity of porcine LEP and LEPR genes involved in growth and fatness regulation.
The presence of leptin and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.
Title: Presence of leptin and its receptor in the hypothalamus, uterus and ovaries of Swine females culled with distinct ovarian statuses and parities.
Studied 3'UTR leptin polymorphism regulatory sequences' affect on gene expression and their association with production traits.
Title: Novel polymorphisms in porcine 3'UTR of the leptin gene, including a rare variant within target sequence for MIR-9 gene in Duroc breed, not associated with production traits.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
Title: Evaluation of effects of multiple candidate genes (LEP, LEPR, MC4R, PIK3C3, and VRTN) on production traits in Duroc pigs.
Data showing changes in expression patterns of LEP/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.
Title: Expression of leptin and its long form receptor at the porcine maternal-fetal interface: contrasting healthy and arresting conceptus attachment sites during early and mid-pregnancy.
Another funning discovery is ob-Rb mRNA in porcine endometrium was mainly negative-regulated by leptin
Title: Expression of obesity gene and obesity gene long form receptor in endometrium of Yorkshire sows during embryo implantation.

Submit: New GeneRIF Correction See all GeneRIFs (35)

General gene information

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Markers

MARC_27654-28472:1067875636:2 (e-PCR)
- UniSTS:269121

LEPHINFI (e-PCR), detects polymorphism
- UniSTS:253262

SB38 (e-PCR), detects polymorphism
- UniSTS:253264

MARC_46115-46116:1108478575:1 (e-PCR)
- UniSTS:471641

LEP-3 (e-PCR)
- UniSTS:253879

MARC_37671-37672:1071255500:2 (e-PCR)
- UniSTS:471532

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info	PubMed
enables peptide hormone receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of protein kinase C activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in energy reserve metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of appetite by leptin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of TOR signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of p38MAPK cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to insulin	IEA Inferred from Electronic Annotation more info	PubMed
involved_in tyrosine phosphorylation of STAT protein	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: leptin

Names: obese; obesity factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.