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FAS Fas cell surface death receptor [ Sus scrofa (pig) ]

Gene ID: 396826, updated on 17-Aug-2024

Summary

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Official Symbol
FASprovided by VGNC
Official Full Name
Fas cell surface death receptorprovided by VGNC
Primary source
VGNC:VGNC:88015
See related
Ensembl:ENSSSCG00000010448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
APT1; TNFRSF6
Expression
Ubiquitous expression in lung (RPKM 4.9), spleen (RPKM 4.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See FAS in Genome Data Viewer
Location:
chromosome: 14
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 14 NC_010456.5 (100927305..100954781)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 14 NC_010456.4 (109911730..109939489)

Chromosome 14 - NC_010456.5Genomic Context describing neighboring genes Neighboring gene STAM binding protein like 1 Neighboring gene actin alpha 2, smooth muscle Neighboring gene uncharacterized LOC106506085 Neighboring gene uncharacterized LOC102164066 Neighboring gene cholesterol 25-hydroxylase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. The involvement of Fas/FasL interaction in porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus co-inoculation-associated lymphocyte apoptosis in vitro. Chang HW, et al. Vet Microbiol, 2007 May 16. PMID 17321702
  2. Expression of Fas but not Fas ligand on fetal pig beta cells. Bai L, et al. Xenotransplantation, 2004 Sep. PMID 15303979
  3. Differential gene expression in endometrium, endometrial lymphocytes, and trophoblasts during successful and abortive embryo implantation. Tayade C, et al. J Immunol, 2006 Jan 1. PMID 16365405
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The expression of FAS and FAS ligand in splenic macrophages co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus is reported
    Title: The involvement of Fas/FasL interaction in porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus co-inoculation-associated lymphocyte apoptosis in vitro.
  2. Fas was expressed on fetal pig pancreatic cells, both beta and non-beta cells, and the level of expression could be upregulated by exposure to interleukin 1beta
    Title: Expression of Fas but not Fas ligand on fetal pig beta cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tumor necrosis factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation-induced cell death of T cells IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in motor neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in necroptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of CD95 death-inducing signaling complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 6
Names
FASLG receptor
Fas (TNF receptor superfamily, member 6)
Fas receptor
apo-1 antigen
apoptosis-mediating surface antigen FAS

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213839.1 → NP_999004.1  tumor necrosis factor receptor superfamily member 6 precursor

    See identical proteins and their annotated locations for NP_999004.1

    Status: VALIDATED

    Source sequence(s)
    AJ001202
    UniProtKB/Swiss-Prot
    O77736
    UniProtKB/TrEMBL
    A0A5G2RGW9
    Related
    ENSSSCP00000074338.1, ENSSSCT00000073478.1
    Conserved Domains (2) summary
    cd08316
    Location:223 → 316
    Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
    cd10579
    Location:37 → 165
    TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010456.5 Reference Sscrofa11.1 Primary Assembly

    Range
    100927305..100954781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021072073.1 → XP_020927732.1  tumor necrosis factor receptor superfamily member 6 isoform X1

    UniProtKB/TrEMBL
    F1SCY7
    Conserved Domains (2) summary
    cd08316
    Location:319 → 412
    Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
    cd10579
    Location:133 → 261
    TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77736.1 GenPept UniProtKB/Swiss-Prot:O77736

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.