DEFB1 defensin, beta 1 [Sus scrofa (pig)] - Gene

Summary

Gene symbol: DEFB1
Gene description: defensin, beta 1
See related: Ensembl:ENSSSCG00000027555
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: PBD1; PBD-1
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: chromosome: 15

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	15	NC_010457.5 (38076057..38077899)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	Unplaced Scaffold	NW_003613575.1 (1895..3712, complement)

Chromosome 15 - NC_010457.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

pBD1 showed low hemolytic activity and high thermal stability. These properties are relevant for the biotechnological applications of the peptide.
Title: Cloning, expression and characterization of antimicrobial porcine β defensin 1 in Escherichia coli.
Zinc sulfate and L-isoleucine induce beta defensin expression in a porcine cell line.
Title: Zn(2+) and L-isoleucine induce the expressions of porcine β-defensins in IPEC-J2 cells.
Presence of beta-defensin 1 in the upper respiratory tract is associated with resistance against respiratory infection with Bordetella pertussis in older piglets
Title: The host defense peptide beta-defensin 1 confers protection against Bordetella pertussis in newborn piglets.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables CCR6 chemokine receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables chemoattractant activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: beta-defensin 1

Names: BD-1; prepro-beta-defensin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.