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AKR1B1 aldo-keto reductase family 1 member B [ Sus scrofa (pig) ]

Gene ID: 396816, updated on 17-Aug-2024

Summary

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Official Symbol
AKR1B1provided by VGNC
Official Full Name
aldo-keto reductase family 1 member Bprovided by VGNC
Primary source
VGNC:VGNC:109454
See related
Ensembl:ENSSSCG00000040608
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
AR; ALR2
Expression
Ubiquitous expression in kidney (RPKM 67.7), ovary (RPKM 57.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See AKR1B1 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
13
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 18 NC_010460.4 (14593516..14752316)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 18 NC_010460.3 (15596806..15614673)

Chromosome 18 - NC_010460.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106506771 Neighboring gene bisphosphoglycerate mutase Neighboring gene sorting nexin-5 pseudogene Neighboring gene phosphopantothenate--cysteine ligase pseudogene Neighboring gene uncharacterized LOC106506773

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil. Urzhumtsev A, et al. Structure, 1997 May 15. PMID 9195881
  2. Location of an essential arginine residue in the primary structure of pig aldose reductase. Kubiseski TJ, et al. Adv Exp Med Biol, 1993. PMID 8493902
  3. Novel NADPH-binding domain revealed by the crystal structure of aldose reductase. Rondeau JM, et al. Nature, 1992 Jan 30. PMID 1734286
  4. Probing flexibility and "induced-fit" phenomena in aldose reductase by comparative crystal structure analysis and molecular dynamics simulations. Sotriffer CA, et al. Proteins, 2004 Jul 1. PMID 15162486
  5. Sequence of pig lens aldose reductase and electrospray mass spectrometry of non-covalent and covalent complexes. Jaquinod M, et al. Eur J Biochem, 1993 Dec 15. PMID 8281941

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. crystal structure analysis and molecular dynamics simulations
    Title: Probing flexibility and "induced-fit" phenomena in aldose reductase by comparative crystal structure analysis and molecular dynamics simulations.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aldose reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
aldo-keto reductase family 1 member B1; aldose reductase
Names
aldehyde reductase
NP_001001539.1
XP_020934156.1
XP_020934157.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001539.2 → NP_001001539.1  aldo-keto reductase family 1 member B1

    See identical proteins and their annotated locations for NP_001001539.1

    Status: PROVISIONAL

    Source sequence(s)
    U46065
    UniProtKB/Swiss-Prot
    P80276
    UniProtKB/TrEMBL
    A0A0B8S0C2, A0A4X1VTL4
    Related
    ENSSSCP00000039171.3, ENSSSCT00000065341.3
    Conserved Domains (2) summary
    COG0656
    Location:1 → 297
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:9 → 289
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010460.4 Reference Sscrofa11.1 Primary Assembly

    Range
    14593516..14752316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021078497.1 → XP_020934156.1  aldose reductase isoform X1

    Conserved Domains (1) summary
    COG0656
    Location:1 → 153
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

  2. XM_021078498.1 → XP_020934157.1  aldose reductase isoform X1

    Conserved Domains (1) summary
    COG0656
    Location:1 → 153
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P80276.2 GenPept UniProtKB/Swiss-Prot:P80276

Gene LinkOut

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