FASLG Fas ligand [Sus scrofa (pig)] - Gene

Summary

Official Symbol: FASLGprovided by VGNC
Official Full Name: Fas ligandprovided by VGNC
Primary source: VGNC:VGNC:103942
See related: Ensembl:ENSSSCG00000022226
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: FASL; CD95-L; TNFSF6
Expression: Broad expression in spleen (RPKM 3.4), lung (RPKM 2.2) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	9	NC_010451.4 (115068314..115075147)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	9	NC_010451.3 (126641066..126647827, complement)

Chromosome 9 - NC_010451.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL and Fas ligand FasL expression during follicular atresia.
Title: Changes in the expression of Fox O1 and death ligand genes during follicular atresia in porcine ovary.
the result indicates that the expression of FasL by chondrocytes is capable of inducing apoptosis of activated T cells
Title: Fas Ligand gene transfer enhances the survival of tissue-engineered chondrocyte allografts in mini-pigs.
The expression of FAS and FAS ligand in splenic macrophages co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus is reported
Title: The involvement of Fas/FasL interaction in porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus co-inoculation-associated lymphocyte apoptosis in vitro.
FasL was not detected on fetal pig pancreatic cells but could be induced on both beta and non-beta cells when the cells were treated with IL1beta.
Title: Expression of Fas but not Fas ligand on fetal pig beta cells.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor ligand superfamily member 6

Names: CD95 ligand; Fas ligand (TNF superfamily, member 6); fas antigen ligand; tumor necrosis factor (ligand) superfamily, member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213806.1 → NP_998971.1 tumor necrosis factor ligand superfamily member 6

See identical proteins and their annotated locations for NP_998971.1

Status: PROVISIONAL

Source sequence(s)

AB027297

UniProtKB/Swiss-Prot

Q95M04, Q95N10, Q9BEA8

UniProtKB/TrEMBL

A0A4X1UHU9, A0A8D1XC76, I3L6W5

Related

ENSSSCP00000019767.2, ENSSSCT00000026331.4

Conserved Domains (1) summary

cd00184
Location:147 → 280

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...