HIF1A hypoxia inducible factor 1 subunit alpha [Sus scrofa (pig)] - Gene

Summary

Official Symbol: HIF1Aprovided by VGNC
Official Full Name: hypoxia inducible factor 1 subunit alphaprovided by VGNC
Primary source: VGNC:VGNC:88880
See related: Ensembl:ENSSSCG00000005096
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Ubiquitous expression in lung (RPKM 32.9), spleen (RPKM 32.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	1	NC_010443.5 (190625436..190673926)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	1	NC_010443.4 (212130958..212179888)

Chromosome 1 - NC_010443.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results of the present study suggest that increases in hypoxia inducible factor 1 subunit alpha( HIF-1alpha) are responsible for initial response to hypoxia that results in a transient cell cycle arrest in trophectoderm cells
Title: Hypoxia-dependent accumulation of hypoxia-inducible factor-1 alpha induces transient cell cycle arrest in porcine trophectoderm cells.
The results showed that 60-min ischemia of the porcine uterus conducted at the mid-secretory estrous phase caused decreased HIF-1alpha and increased SOD-2 gene expression.
Title: Expression of hypoxia inducible factor 1α and antioxidant enzymes: Superoxide dismutases-1 and -2 in ischemic porcine endometrium.
a high expression of hypoxia induced factor-1a (HIF-1a) and heat shock protein 70 (HSP70) was noted
Title: Degenerative effects of cobalt-chloride treatment on neurons and microglia in a porcine retina organ culture model.
Induction of ischemic osteonecrosis results in IL-6 production in the articular cartilage through an HIF-1-dependent pathway.
Title: HIF-1-Dependent IL-6 Activation in Articular Chondrocytes Initiating Synovitis in Femoral Head Ischemic Osteonecrosis.
Upregulation of VEGF during hypoxia in chondrocyte is mediated partially through HIF-1alpha.
Title: Regulation of VEGF expression by HIF-1α in the femoral head cartilage following ischemia osteonecrosis.
HIF-1alpha activates Sox9 expression and enhances Sox9-mediated transcriptional activity.
Title: Hypoxia-inducible factor-1 is a positive regulator of Sox9 activity in femoral head osteonecrosis.
Intramyocardial delivery of mesenchymal stem cells seems to trigger the release of angiogenic HIF-1alpha more effectively than does intracoronary delivery.
Title: Hypoxia-inducible factor 1-alpha release after intracoronary versus intramyocardial stem cell therapy in myocardial infarction.
immunostaining for HIF-1alpha and HIF-2alpha was observed during endochondral ossification, whereas only HIF-2alpha was present at sites of intramembranous ossification
Title: Detection of hypoxia inducible factors and angiogenic growth factors during foetal endochondral and intramembranous ossification.
Viable chondrocytes in the superficial layer of the epiphyseal cartilage showed HIF-1alpha activation and VEGF upregulation with subsequent revascularization occurring in the cartilage.
Title: Hypoxia and HIF-1alpha expression in the epiphyseal cartilage following ischemic injury to the immature femoral head.
Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.
Title: Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.

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General gene information

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Markers

HIF1A (e-PCR)
- UniSTS:511803

MARC_6691-6694:992007331:1 (e-PCR)
- UniSTS:231249

PMC212228P2 (e-PCR)
- UniSTS:272019

SGC35483 (e-PCR)
- UniSTS:72875

MARC_11585-11586:1002657151:1 (e-PCR)
- UniSTS:267233

MARC_11585-11586:1007154223:1 (e-PCR)
- UniSTS:267233

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: hypoxia-inducible factor 1-alpha

Names: hypoxia inducible factor 1 alpha subunit; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1 alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001123124.1 → NP_001116596.1 hypoxia-inducible factor 1-alpha

See identical proteins and their annotated locations for NP_001116596.1

Status: PROVISIONAL

Source sequence(s)

EF070345

UniProtKB/TrEMBL

A0A287B2Q0, A0A4X1WCR0, A0T1H6

Related

ENSSSCP00000050717.2, ENSSSCT00000051506.2

Conserved Domains (6) summary

smart00091
Location:93 → 148

PAS; PAS domain

cd00083
Location:15 → 68

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cd00130
Location:239 → 338

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08447
Location:254 → 339

PAS_3; PAS fold

pfam08778
Location:787 → 823

HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain

pfam11413
Location:552 → 582

HIF-1; Hypoxia-inducible factor-1