Tak1 TGF-beta activated kinase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tak1provided by FlyBase
Official Full Name: TGF-beta activated kinase 1provided by FlyBase
Primary source: FLYBASE:FBgn0026323
Locus tag: Dmel_CG18492
See related: AllianceGenome:FB:FBgn0026323
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1388; CG18492; D-tak; D-TAK; D10; Dmel\CG18492; DmTak1; dTak; dTAK; DTak; dTAK-1; dtak1; dTak1; dTAK1; DTak1; DTAK1; tak; Tak; TAK; Tak 1; TAK-1; tak1; TAK1
Summary: Enables JUN kinase kinase kinase activity and ubiquitin protein ligase binding activity. Involved in several processes, including morphogenesis of an epithelium; positive regulation of intracellular signal transduction; and response to bacterium. Located in cytoplasm. Is expressed in adult Malpighian tubule and organism. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia; frontometaphyseal dysplasia 2; and prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 19D2-19D2; 1-64 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (20515908..20524928, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (20386935..20395955, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Relish-mediated C2H2 zinc finger protein IMZF restores Drosophila immune homeostasis via inhibiting the transcription of Imd/Tak1.
Title: Relish-mediated C2H2 zinc finger protein IMZF restores Drosophila immune homeostasis via inhibiting the transcription of Imd/Tak1.
Drosophila eIF3f1 mediates host immune defense by targeting dTak1.
Title: Drosophila eIF3f1 mediates host immune defense by targeting dTak1.
Imd is rapidly Lys-63-polyubiquitinated at lysine residues 137 and 153 by the sequential action of two E2 enzymes, Ubc5 and Ubc13-Uev1a, in conjunction with the E3 ligase Diap2. Lys-63-ubiquitination activates the TGFbeta-activated kinase (Tak1), which feeds back to phosphorylate Imd, triggering the removal of Lys-63 chains and the addition of Lys-48 polyubiquitin.
Title: Innate immune signaling in Drosophila is regulated by transforming growth factor β (TGFβ)-activated kinase (Tak1)-triggered ubiquitin editing.
Tak1 is dispensable in the Slpr-dependent process of dorsal closure; it does not induce or inhibit morphogenetic JNK signaling.
Title: Domain specificity of MAP3K family members, MLK and Tak1, for JNK signaling in Drosophila.
The data data uncover Rab8, POSH, and TAK1 as regulators of synaptic growth responses and point to recycling endosome as a key compartment for synaptic growth regulation during neurodegenerative processes.
Title: Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia.
The TAK1-associated Binding Protein 2 (TAB2) was linked with the TAK1-Trabid interaction through its Zinc finger domain that pacified the TAK1 signal
Title: Loss of Trabid, a new negative regulator of the drosophila immune-deficiency pathway at the level of TAK1, reduces life span.
When treated with autophagy inhibitors, the level of TAK1-induced cytotoxicity or cell death was significantly attenuated, indicating that TAK1 induces cytotoxic autophagic cell death.
Title: TAK1 regulates autophagic cell death by suppressing the phosphorylation of p70 S6 kinase 1.
evidence that TAK1 is a target for YopJ-mediated inhibition.
Title: Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling.
that dpp induced non-autonomous apoptosis through TGFbeta activated kinase 1 (TAK1)
Title: Excessive Dpp signaling induces cardial apoptosis through dTAK1 and dJNK during late embryogenesis of Drosophila.
TAK1 functions as both the Drosophila IkappaB kinase-activating kinase and the JNK kinase-activating kinase
Title: Immune activation of NF-kappaB and JNK requires Drosophila TAK1.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables MAP kinase kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in notum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ommatidial rotation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antibacterial peptide biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment of planar polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: TGF-beta activated kinase 1

Names: CG18492-PA; CG18492-PB; TGF beta-activated kinase 1; TGF-beta activated-kinase 1; TGFbeta-activated kinase 1; Tak1-PA; Tak1-PB; transforming growth factor beta-activated kinase; transforming growth factor-beta activated kinase 1; transforming growth factor-beta-activated kinase 1

NP_001285498.1

EC 2.7.11.1

EC 2.7.11.25

NP_524080.1

EC 2.7.11.1

EC 2.7.11.25

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

20515908..20524928 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079356.3 → NP_524080.1 TGF-beta activated kinase 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524080.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3Q6

Related

FBpp0077011

Conserved Domains (2) summary

smart00219
Location:19 → 264

TyrKc; Tyrosine kinase, catalytic domain

cd14058
Location:25 → 275

STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1
NM_001298569.1 → NP_001285498.1 TGF-beta activated kinase 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285498.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JFZ3