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CNTF ciliary neurotrophic factor [ Gallus gallus (chicken) ]

Gene ID: 396488, updated on 17-Aug-2024

Summary

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Symbol
CNTFprovided by CGNC
Full Name
ciliary neurotrophic factorprovided by CGNC
Primary source
CGNC:49832
See related
Ensembl:ENSGALG00010026105
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
CNF; GPA
Orthologs
human mouse all
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Genomic context

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See CNTF in Genome Data Viewer
Location:
chromosome: 5
Exon count:
3
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (16475246..16478221, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (16435521..16438496, complement)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene scavenger receptor cysteine-rich type 1 protein M130-like Neighboring gene uncharacterized LOC121113262 Neighboring gene macrophage expressed 1 Neighboring gene deltex E3 ubiquitin ligase 4 Neighboring gene ZFP91 ZFP91 zinc finger protein Neighboring gene leupaxin Neighboring gene catenin delta 1 Neighboring gene uncharacterized LOC121106534

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification and characterization of a trophic factor for embryonic peripheral neurons: comparison with fibroblast growth factors. Eckenstein FP, et al. Neuron, 1990 Apr. PMID 2322465
  2. Cloning, expression during development, and evidence for release of a trophic factor for ciliary ganglion neurons. Leung DW, et al. Neuron, 1992 Jun. PMID 1610564
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ciliary neurotrophic factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in astrocyte activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ciliary neurotrophic factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of axon regeneration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ciliary neurotrophic factor
Names
growth-promoting activity factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205492.1 → NP_990823.1  ciliary neurotrophic factor

    See identical proteins and their annotated locations for NP_990823.1

    Status: PROVISIONAL

    Source sequence(s)
    M80827
    UniProtKB/Swiss-Prot
    Q02011
    Related
    ENSGALP00010039259.1, ENSGALT00010063604.1
    Conserved Domains (1) summary
    pfam01110
    Location:1 → 187
    CNTF; Ciliary neurotrophic factor

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    16475246..16478221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046941525.1 → XP_046797481.1  ciliary neurotrophic factor isoform X1

    UniProtKB/Swiss-Prot
    Q02011

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    16435521..16438496 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046917967.1 → XP_046773923.1  ciliary neurotrophic factor isoform X1

    UniProtKB/Swiss-Prot
    Q02011
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02011.1 GenPept UniProtKB/Swiss-Prot:Q02011

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials