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TNS1 tensin 1 [ Gallus gallus (chicken) ]

Gene ID: 396439, updated on 10-Oct-2024

Summary

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Symbol
TNS1provided by CGNC
Full Name
tensin 1provided by CGNC
Primary source
CGNC:66228
See related
Ensembl:ENSGALG00010019050
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
TNS
Orthologs
human mouse all
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Genomic context

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See TNS1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
39
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (22218576..22272601)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (22138226..22192253)

Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene angio associated migratory cell protein Neighboring gene actin related protein 2/3 complex subunit 2 Neighboring gene C-X-C motif chemokine receptor 1 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene uncharacterized LOC101749755 Neighboring gene uncharacterized LOC101749715

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Modulation of tensin and vimentin expression in chick embryo developing cartilage and cultured differentiating chondrocytes. van de Werken R, et al. Eur J Biochem, 1993 Oct 15. PMID 8223621
  2. Molecular cloning of chick cardiac muscle tensin. Full-length cDNA sequence, expression, and characterization. Lo SH, et al. J Biol Chem, 1994 Sep 2. PMID 8071358
  3. Molecular cloning, expression, and mapping of the high affinity actin-capping domain of chicken cardiac tensin. Chuang JZ, et al. J Cell Biol, 1995 Mar. PMID 7896874, Free PMC Article
  4. Presence of an SH2 domain in the actin-binding protein tensin. Davis S, et al. Science, 1991 May 3. PMID 1708917
  5. Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities. Qian X, et al. Proc Natl Acad Sci U S A, 2007 May 22. PMID 17517630, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in fibroblast migration IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tensin-1; tensin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396437.1 → NP_001383366.1  tensin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000236
    UniProtKB/Swiss-Prot
    A0A1L1RRE9, Q04205, Q91007, Q92011
    Conserved Domains (5) summary
    cd09927
    Location:1468 → 1583
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:986 → 1415
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:648 → 954
    PRK10263; DNA translocase FtsK; Provisional
    cd01213
    Location:1605 → 1738
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14560
    Location:68 → 226
    PTP_tensin-1; protein tyrosine phosphatase-like domain of tensin-1

  2. NM_001396438.1 → NP_001383367.1  tensin-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000236
    Conserved Domains (5) summary
    smart00109
    Location:21 → 67
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd09927
    Location:945 → 1060
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:472 → 889
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1082 → 1215
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14560
    Location:121 → 279
    PTP_tensin-1; protein tyrosine phosphatase-like domain of tensin-1

  3. NM_001396440.1 → NP_001383369.1  tensin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000236
    UniProtKB/TrEMBL
    A0A8V0ZA33
    Related
    ENSGALP00010027501.1, ENSGALT00010046138.1
    Conserved Domains (5) summary
    cd09927
    Location:1456 → 1571
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:825 → 1382
    PHA03247; large tegument protein UL36; Provisional
    PRK07003
    Location:670 → 955
    PRK07003; DNA polymerase III subunit gamma/tau
    cd01213
    Location:1593 → 1726
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14560
    Location:68 → 226
    PTP_tensin-1; protein tyrosine phosphatase-like domain of tensin-1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    22218576..22272601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046943529.1 → XP_046799485.1  tensin isoform X9

  2. XM_046943524.1 → XP_046799480.1  tensin isoform X4

    Related
    ENSGALP00010027502.1, ENSGALT00010046143.1

  3. XM_046943527.1 → XP_046799483.1  tensin isoform X7

    Related
    ENSGALP00010027503.1, ENSGALT00010046145.1

  4. XM_046943534.1 → XP_046799490.1  tensin isoform X14

  5. XM_046943535.1 → XP_046799491.1  tensin isoform X15

  6. XM_046943531.1 → XP_046799487.1  tensin isoform X11

  7. XM_046943533.1 → XP_046799489.1  tensin isoform X13

  8. XM_046943521.1 → XP_046799477.1  tensin isoform X1

  9. XM_046943522.1 → XP_046799478.1  tensin isoform X2

  10. XM_046943525.1 → XP_046799481.1  tensin isoform X5

  11. XM_046943528.1 → XP_046799484.1  tensin isoform X8

  12. XM_046943526.1 → XP_046799482.1  tensin isoform X6

  13. XM_046943530.1 → XP_046799486.1  tensin isoform X10

  14. XM_046943532.1 → XP_046799488.1  tensin isoform X12

    Related
    ENSGALP00010027500.1, ENSGALT00010046135.1

  15. XM_046943538.1 → XP_046799494.1  tensin isoform X17

  16. XM_046943523.1 → XP_046799479.1  tensin isoform X3

  17. XM_046943537.1 → XP_046799493.1  tensin isoform X16

  18. XM_046943536.1 → XP_046799492.1  tensin isoform X16

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    22138226..22192253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046921198.1 → XP_046777154.1  tensin isoform X9

  2. XM_046921192.1 → XP_046777148.1  tensin isoform X4

  3. XM_046921196.1 → XP_046777152.1  tensin isoform X7

  4. XM_046921203.1 → XP_046777159.1  tensin isoform X14

  5. XM_046921204.1 → XP_046777160.1  tensin isoform X15

  6. XM_046921200.1 → XP_046777156.1  tensin isoform X11

  7. XM_046921202.1 → XP_046777158.1  tensin isoform X13

  8. XM_046921189.1 → XP_046777145.1  tensin isoform X1

  9. XM_046921190.1 → XP_046777146.1  tensin isoform X2

  10. XM_046921193.1 → XP_046777149.1  tensin isoform X5

  11. XM_046921197.1 → XP_046777153.1  tensin isoform X8

  12. XM_046921194.1 → XP_046777150.1  tensin isoform X6

  13. XM_046921199.1 → XP_046777155.1  tensin isoform X10

  14. XM_046921201.1 → XP_046777157.1  tensin isoform X12

  15. XM_046921208.1 → XP_046777164.1  tensin isoform X17

  16. XM_046921191.1 → XP_046777147.1  tensin isoform X3

  17. XM_046921207.1 → XP_046777163.1  tensin isoform X16

  18. XM_046921205.1 → XP_046777161.1  tensin isoform X16

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_205455.1: Suppressed sequence

    Description
    NM_205455.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04205.3 GenPept UniProtKB/Swiss-Prot:Q04205

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