TPI1 triosephosphate isomerase 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: TPI1provided by CGNC
Full Name: triosephosphate isomerase 1provided by CGNC
Primary source: CGNC:49803
See related: Ensembl:ENSGALG00010023392
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: TIM
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (77223631..77226616)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (77423866..77426847)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1st essential mode contributing to 34% of overall motion of dimer is strongly coupled to loop 6's closure over active site. Onset of collective motions at ns time scale due to dimerization has functional implications as to coordination of loop 6 closure.
Title: Dimerization affects collective dynamics of triosephosphate isomerase.
There is clear evidence for motion with an exchange rate constant consistent with opening and closing of triosephosphate isomerase active site loop (loop 6) being partially rate-limiting to catalytic throughput.
Title: Value of a hydrogen bond in triosephosphate isomerase loop motion.
The hypothesis that limited access to conformational space is a requirement for protein hinges involved in catalysis has been successfully tested with glycine N- and C-terminal hinge mutants of loop 6 of triosephosphate isomerase (TIM).
Title: Entropy effects on protein hinges: the reaction catalyzed by triosephosphate isomerase.
NMR study of wild-type (WT) TIM and a quintuple mutant (PGG/GGG).
Title: Dynamic requirements for a functional protein hinge.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables triose-phosphate isomerase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in glyceraldehyde-3-phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in glycerol catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: triosephosphate isomerase

Names: methylglyoxal synthase; triose-phosphate isomerase; triosephosphate isomerase (TIM, D-glyceraldehyde 3-phosphate ketol-isomerase)

NP_990782.1

EC 4.2.3.3

EC 5.3.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.