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LGALS8 galectin 8 [ Homo sapiens (human) ]

Gene ID: 3964, updated on 2-Nov-2024

Summary

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Official Symbol
LGALS8provided by HGNC
Official Full Name
galectin 8provided by HGNC
Primary source
HGNC:HGNC:6569
See related
Ensembl:ENSG00000116977 MIM:606099; AllianceGenome:HGNC:6569
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Gal-8; PCTA1; PCTA-1; Po66-CBP
Summary
This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 17.5), skin (RPKM 16.3) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See LGALS8 in Genome Data Viewer
Location:
1q43
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (236518214..236552981)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (235919116..235953936)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (236681514..236716281)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2821 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:236528741-236529521 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2822 Neighboring gene MPRA-validated peak784 silencer Neighboring gene EDAR associated via death domain Neighboring gene ReSE screen-validated silencer GRCh37_chr1:236553124-236553300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:236588023-236588524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2003 Neighboring gene NANOG hESC enhancer GRCh37_chr1:236634853-236635427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:236636352-236636876 Neighboring gene Sharpr-MPRA regulatory region 2344 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:236679601-236679779 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2004 Neighboring gene enolase 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 1811 Neighboring gene LGALS8 antisense RNA 1 Neighboring gene MPRA-validated peak785 silencer Neighboring gene MPRA-validated peak786 silencer Neighboring gene HEAT repeat containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2825 Neighboring gene MPRA-validated peak787 silencer Neighboring gene control region 3 heart enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2005 Neighboring gene VISTA enhancer hs2135 Neighboring gene actinin alpha 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2826 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2827 Neighboring gene ribosomal protein SA pseudogene 21 Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Non-synonymous single nucleotide polymorphisms in genes for immunoregulatory galectins: association of galectin-8 (F19Y) occurrence with autoimmune diseases in a Caucasian population. Pál Z, et al. Biochim Biophys Acta, 2012 Oct. PMID 22683700
  2. Galectin-8 mediates fibrogenesis induced by cyclosporine in human gingival fibroblasts. Smith PC, et al. J Periodontal Res, 2020 Oct. PMID 32449990
  3. Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation. Massardo L, et al. Lupus, 2009 May. PMID 19395456
  4. Crystallization and preliminary X-ray diffraction analysis of a protease-resistant mutant form of human galectin-8. Yoshida H, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 May 1. PMID 19407390, Free PMC Article
  5. Galectin-8 up-regulation during hypopharyngeal and laryngeal tumor progression and comparison with galectin-1, -3 and -7. Cludts S, et al. Anticancer Res, 2009 Dec. PMID 20044599

See all (131) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Galectin-8 Contributes to Human Trophoblast Cell Invasion.
    Title: Galectin-8 Contributes to Human Trophoblast Cell Invasion.
  2. Expression of Intracellular Galectin-8 and -9 in Endometrial Cancer.
    Title: Expression of Intracellular Galectin-8 and -9 in Endometrial Cancer.
  3. Hypoxia-induced galectin-8 maintains stemness in glioma stem cells via autophagy regulation.
    Title: Hypoxia-induced galectin-8 maintains stemness in glioma stem cells via autophagy regulation.
  4. Association of GAL-8 promoter methylation levels with coronary plaque inflammation.
    Title: Association of GAL-8 promoter methylation levels with coronary plaque inflammation.
  5. Galectin-8 modulates human osteoclast activity partly through isoform-specific interactions.
    Title: Galectin-8 modulates human osteoclast activity partly through isoform-specific interactions.
  6. Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens.
    Title: Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens.
  7. Galectin-8 and -9 as prognostic factors for cervical cancer.
    Title: Galectin-8 and -9 as prognostic factors for cervical cancer.
  8. Selective Monovalent Galectin-8 Ligands Based on 3-Lactoylgalactoside.
    Title: Selective Monovalent Galectin-8 Ligands Based on 3-Lactoylgalactoside.
  9. circHMGCS1-016 reshapes immune environment by sponging miR-1236-3p to regulate CD73 and GAL-8 expression in intrahepatic cholangiocarcinoma.
    Title: circHMGCS1-016 reshapes immune environment by sponging miR-1236-3p to regulate CD73 and GAL-8 expression in intrahepatic cholangiocarcinoma.
  10. Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.
    Title: Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.
Submit: New GeneRIF Correction See all GeneRIFs (73)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of LGALS8 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables integrin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lymphatic endothelial cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space TAS
Traceable Author Statement
more info
 PubMed 
located_in membrane HDA PubMed 

General protein information

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Preferred Names
galectin-8
Names
Po66 carbohydrate binding protein
galectin-8g
lectin, galactoside-binding, soluble, 8
po66 carbohydrate-binding protein
prostate carcinoma tumor antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006499.5 → NP_006490.3  galectin-8 isoform a

    See identical proteins and their annotated locations for NP_006490.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 4 encode the longer isoform (a).
    Source sequence(s)
    AK098613, AL359921, BC016486, DB053616
    Consensus CDS
    CCDS1611.1
    UniProtKB/TrEMBL
    F6V2D4
    Related
    ENSP00000408657.2, ENST00000450372.6
    Conserved Domains (2) summary
    smart00908
    Location:236 → 356
    Gal-bind_lectin; Galactoside-binding lectin
    pfam00337
    Location:18 → 151
    Gal-bind_lectin; Galactoside-binding lectin

  2. NM_201543.4 → NP_963837.1  galectin-8 isoform b

    See identical proteins and their annotated locations for NP_963837.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. Variants 2 and 3 encode a shorter isoform (b) that is missing an internal segment compared to isoform a.
    Source sequence(s)
    AL359921, BC016486, DB053616
    Consensus CDS
    CCDS1612.1
    UniProtKB/Swiss-Prot
    O00214, O15215, Q5T3P5, Q5T3Q4, Q8TEV1, Q96B92, Q9BXC8, Q9H584, Q9H585, Q9UEZ6, Q9UP32, Q9UP33, Q9UP34
    UniProtKB/TrEMBL
    Q59E97
    Related
    ENSP00000342139.6, ENST00000341872.10
    Conserved Domains (2) summary
    smart00908
    Location:194 → 314
    Gal-bind_lectin; Galactoside-binding lectin
    pfam00337
    Location:18 → 151
    Gal-bind_lectin; Galactoside-binding lectin

  3. NM_201544.4 → NP_963838.1  galectin-8 isoform b

    See identical proteins and their annotated locations for NP_963838.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame segment of the coding region, compared to variant 1. Variants 2 and 3 encode a shorter isoform (b) that is missing an internal segment compared to isoform a.
    Source sequence(s)
    AL359921, BC016486
    Consensus CDS
    CCDS1612.1
    UniProtKB/Swiss-Prot
    O00214, O15215, Q5T3P5, Q5T3Q4, Q8TEV1, Q96B92, Q9BXC8, Q9H584, Q9H585, Q9UEZ6, Q9UP32, Q9UP33, Q9UP34
    UniProtKB/TrEMBL
    Q59E97
    Related
    ENSP00000355543.4, ENST00000366584.9
    Conserved Domains (2) summary
    smart00908
    Location:194 → 314
    Gal-bind_lectin; Galactoside-binding lectin
    pfam00337
    Location:18 → 151
    Gal-bind_lectin; Galactoside-binding lectin

  4. NM_201545.2 → NP_963839.1  galectin-8 isoform a

    See identical proteins and their annotated locations for NP_963839.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1 and 4 encode a longer isoform (a).
    Source sequence(s)
    AK098613, AL359921, BC016486, BP371701
    Consensus CDS
    CCDS1611.1
    UniProtKB/TrEMBL
    F6V2D4
    Related
    ENSP00000309576.2, ENST00000352231.6
    Conserved Domains (2) summary
    smart00908
    Location:236 → 356
    Gal-bind_lectin; Galactoside-binding lectin
    pfam00337
    Location:18 → 151
    Gal-bind_lectin; Galactoside-binding lectin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    236518214..236552981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420410.1 → XP_047276366.1  galectin-8 isoform X1

    Related
    ENSP00000435460.1, ENST00000526589.5

  2. XM_047420411.1 → XP_047276367.1  galectin-8 isoform X1

  3. XM_047420409.1 → XP_047276365.1  galectin-8 isoform X1

  4. XM_047420416.1 → XP_047276372.1  galectin-8 isoform X3

    UniProtKB/Swiss-Prot
    O00214, O15215, Q5T3P5, Q5T3Q4, Q8TEV1, Q96B92, Q9BXC8, Q9H584, Q9H585, Q9UEZ6, Q9UP32, Q9UP33, Q9UP34

  5. XM_011544188.4 → XP_011542490.1  galectin-8 isoform X2

    Conserved Domains (2) summary
    smart00908
    Location:236 → 310
    Gal-bind_lectin; Galactoside-binding lectin
    pfam00337
    Location:18 → 151
    Gal-bind_lectin; Galactoside-binding lectin

  6. XM_017001274.3 → XP_016856763.1  galectin-8 isoform X4

    UniProtKB/TrEMBL
    E9PN19

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    235919116..235953936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336565.1 → XP_054192540.1  galectin-8 isoform X1

  2. XM_054336566.1 → XP_054192541.1  galectin-8 isoform X1

  3. XM_054336564.1 → XP_054192539.1  galectin-8 isoform X1

  4. XM_054336567.1 → XP_054192542.1  galectin-8 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00214.4 GenPept UniProtKB/Swiss-Prot:O00214

Gene LinkOut

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