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IRF8 interferon regulatory factor 8 [ Gallus gallus (chicken) ]

Gene ID: 396385, updated on 10-Oct-2024

Summary

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Symbol
IRF8provided by CGNC
Full Name
interferon regulatory factor 8provided by CGNC
Primary source
CGNC:49782
See related
Ensembl:ENSGALG00010006715
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
ICSBP; ICSBP1
Annotation information
Annotation category: suggests misassembly
Orthologs
human mouse all
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Genomic context

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See IRF8 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
10
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 11 NC_052542.1 (17237123..17244589, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 11 NC_052583.1 (17584730..17592148, complement)

Chromosome 11 - NC_052542.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112533284 Neighboring gene uncharacterized LOC107054325 Neighboring gene dual specificity protein phosphatase 22-A-like Neighboring gene cytochrome c oxidase subunit 4I1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chicken interferon consensus sequence-binding protein (ICSBP) and interferon regulatory factor (IRF) 1 genes reveal evolutionary conservation in the IRF gene family. Jungwirth C, et al. Proc Natl Acad Sci U S A, 1995 Apr 11. PMID 7536924, Free PMC Article
  2. Regulation of telomerase activity by interferon regulatory factors 4 and 8 in immune cells. Hrdlicková R, et al. Mol Cell Biol, 2009 Feb. PMID 19047367, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interferon regulatory factor 8
Names
IRF-8
interferon consensus sequence binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205416.1 → NP_990747.1  interferon regulatory factor 8

    See identical proteins and their annotated locations for NP_990747.1

    Status: PROVISIONAL

    Source sequence(s)
    L39767
    UniProtKB/Swiss-Prot
    Q90871
    UniProtKB/TrEMBL
    A0A8V0XZ20
    Conserved Domains (2) summary
    pfam00605
    Location:9 → 113
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:205 → 383
    IRF-3; Interferon-regulatory factor 3

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052542.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    17237123..17244589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040707014.2 → XP_040562948.1  interferon regulatory factor 8 isoform X2

    Conserved Domains (1) summary
    smart00348
    Location:9 → 115
    IRF; interferon regulatory factor

  2. XM_015292551.4 → XP_015148037.1  interferon regulatory factor 8 isoform X1

    UniProtKB/Swiss-Prot
    Q90871
    UniProtKB/TrEMBL
    A0A8V0XZ20
    Related
    ENSGALP00010009233.1, ENSGALT00010016060.1
    Conserved Domains (2) summary
    pfam00605
    Location:9 → 113
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:205 → 383
    IRF-3; Interferon-regulatory factor 3

  3. XM_015292552.4 → XP_015148038.1  interferon regulatory factor 8 isoform X1

    UniProtKB/Swiss-Prot
    Q90871
    UniProtKB/TrEMBL
    A0A8V0XZ20
    Conserved Domains (2) summary
    pfam00605
    Location:9 → 113
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:205 → 383
    IRF-3; Interferon-regulatory factor 3

  4. XM_015292553.4 → XP_015148039.1  interferon regulatory factor 8 isoform X1

    UniProtKB/Swiss-Prot
    Q90871
    UniProtKB/TrEMBL
    A0A8V0XZ20
    Conserved Domains (2) summary
    pfam00605
    Location:9 → 113
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:205 → 383
    IRF-3; Interferon-regulatory factor 3

  5. XM_046899389.1 → XP_046755345.1  interferon regulatory factor 8 isoform X3

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052583.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    17584730..17592148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046925372.1 → XP_046781328.1  interferon regulatory factor 8 isoform X2

  2. XM_046925369.1 → XP_046781325.1  interferon regulatory factor 8 isoform X1

    UniProtKB/Swiss-Prot
    Q90871

  3. XM_046925370.1 → XP_046781326.1  interferon regulatory factor 8 isoform X1

    UniProtKB/Swiss-Prot
    Q90871

  4. XM_046925371.1 → XP_046781327.1  interferon regulatory factor 8 isoform X1

    UniProtKB/Swiss-Prot
    Q90871

  5. XM_046925373.1 → XP_046781329.1  interferon regulatory factor 8 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90871.1 GenPept UniProtKB/Swiss-Prot:Q90871

Gene LinkOut

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Molecular Biology Databases
Research Materials