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DNTT DNA nucleotidylexotransferase [ Gallus gallus (chicken) ]

Gene ID: 396351, updated on 10-Oct-2024

Summary

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Symbol
DNTTprovided by CGNC
Full Name
DNA nucleotidylexotransferaseprovided by CGNC
Primary source
CGNC:5270
See related
Ensembl:ENSGALG00010021672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
TDT
Orthologs
human mouse all
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Genomic context

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See DNTT in Genome Data Viewer
Location:
chromosome: 6
Exon count:
12
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (21976196..22086355)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (21867265..21977425)

Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100859611 Neighboring gene zinc finger protein 518A Neighboring gene cyclin J Neighboring gene SH2 domain containing 6 Neighboring gene heparan sulfate glucosamine 3-O-sulfotransferase 1-like Neighboring gene uncharacterized LOC121113371 Neighboring gene VENT homeobox Neighboring gene microRNA 202

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. T-cell specific avian TdT: characterization of the cDNA and recombinant enzyme. Yang B, et al. Nucleic Acids Res, 1995 Jun 11. PMID 7596835, Free PMC Article
  2. Mutational analysis of residues in the nucleotide binding domain of human terminal deoxynucleotidyl transferase. Yang B, et al. J Biol Chem, 1994 Apr 22. PMID 8163485
  3. Chicken blastoderms and primordial germ cells possess a higher expression of DNA repair genes and lower expression of apoptosis genes to preserve their genome stability. Rengaraj D, et al. Sci Rep, 2022 Jan 7. PMID 34997179, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNTT shows higher fold expression primarily in EGK.X blastoderms and secondarily in primordial germ cells compared to chicken embryonic fibroblasts.
    Title: Chicken blastoderms and primordial germ cells possess a higher expression of DNA repair genes and lower expression of apoptosis genes to preserve their genome stability.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA nucleotidylexotransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair via nonhomologous end joining IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA nucleotidylexotransferase
Names
deoxynucleotidyltransferase, terminal
terminal addition enzyme
terminal deoxynucleotidyl transferase
terminal deoxynucleotidyltransferase
terminal transferase
NP_990720.3
XP_040558241.1
XP_046775914.1
XP_046775915.1
XP_046798725.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205389.3 → NP_990720.3  DNA nucleotidylexotransferase

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000232
    UniProtKB/Swiss-Prot
    P36195
    Related
    ENSGALP00010031565.1, ENSGALT00010052659.1
    Conserved Domains (2) summary
    smart00483
    Location:163 → 513
    POLXc; DNA polymerase X family
    cd18443
    Location:31 → 125
    BRCT_DNTT; BRCT domain of DNA nucleotidylexotransferase (DNTT) and similar proteins

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    21976196..22086355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046942769.1 → XP_046798725.1  DNA nucleotidylexotransferase isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZL84
    Related
    ENSGALP00010031556.1, ENSGALT00010052651.1

  2. XM_040702307.2 → XP_040558241.1  DNA nucleotidylexotransferase isoform X2

    UniProtKB/Swiss-Prot
    P36195
    Conserved Domains (2) summary
    smart00483
    Location:166 → 432
    POLXc; DNA polymerase X family
    cd18443
    Location:31 → 125
    BRCT_DNTT; BRCT domain of DNA nucleotidylexotransferase (DNTT) and similar proteins

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    21867265..21977425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046919958.1 → XP_046775914.1  DNA nucleotidylexotransferase isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZL84

  2. XM_046919959.1 → XP_046775915.1  DNA nucleotidylexotransferase isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36195.1 GenPept UniProtKB/Swiss-Prot:P36195

Gene LinkOut

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Molecular Biology Databases
Research Materials