CTSD cathepsin D [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: CTSDprovided by CGNC
Official Full Name: cathepsin Dprovided by CGNC
Primary source: CGNC:4989
See related: Ensembl:ENSGALG00010024624
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	5	NC_052536.1 (13730654..13744045)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	5	NC_052577.1 (13699141..13712531)

Chromosome 5 - NC_052536.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chicken CTSD variants are associated with egg quality traits.
Title: Detection of SNPs in the cathepsin D gene and their association with yolk traits in chickens.
Further studies are needed to assess whether "similar to nothepsin" assists cathepsin D in the proteolytic processing of egg yolk proteins during follicular growth.
Title: Sex- and tissue-specific expression of "similar to nothepsin" and cathepsin D in relation to egg yolk formation in Gallus gallus.
Analysis of Gremlin-/- and Dkk-/- mouse mutants and local treatments with BMP proteins reveal that the expression of cathepsin B and D genes is regulated by BMP signaling
Title: Lysosomal cathepsins in embryonic programmed cell death.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in lysosome	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cathepsin D

Names: cathepsin D (lysosomal aspartyl peptidase); cathepsin D (lysosomal aspartyl protease); prepro-cathepsin D, prepro-CD

NP_990508.1

EC 3.4.23.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205177.2 → NP_990508.1 cathepsin D precursor

See identical proteins and their annotated locations for NP_990508.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000214

UniProtKB/Swiss-Prot

Q05744

Related

ENSGALP00010036849.1, ENSGALT00010060089.1

Conserved Domains (3) summary

cd05490
Location:72 → 396

Cathepsin_D2; Cathepsin_D2, pepsin family of proteinases

pfam00026
Location:77 → 397

Asp; Eukaryotic aspartyl protease

pfam07966
Location:21 → 40

A1_Propeptide; A1 Propeptide