NKX2-5 NK2 homeobox 5 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: NKX2-5provided by CGNC
Official Full Name: NK2 homeobox 5provided by CGNC
Primary source: CGNC:2083
See related: Ensembl:ENSGALG00010009324
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: NKX2E; NKX-2.5; CNKX-2.5
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	13	NC_052544.1 (8816351..8818645, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	13	NC_052585.1 (8822068..8824363, complement)

Chromosome 13 - NC_052544.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that myocardial markers ISL1, TNNI2 and NKX2-5 and HCN4 were studied in sequential stages of chick embryo development.
Title: The sinus venosus myocardium contributes to the atrioventricular canal: potential role during atrioventricular node development?
characterized the cis-regulatory elements of the tinman homolog Nkx2.5
Title: SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer.
Nkx2.5 autoregulation is evolutionarily conserved in the second heart field
Title: Evolutionary conservation of Nkx2.5 autoregulation in the second heart field.
Overexpression of Nkx2-5 causes inhibition of slow tonic myosin heavy chain protein, a late Purkinje fiber marker, but does not affect Cx40 levels
Title: Differentiation of cardiac Purkinje fibers requires precise spatiotemporal regulation of Nkx2-5 expression.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: homeobox protein Nkx-2.5

Names: NK2 transcription factor related, locus 5; homeobox protein NK-2 homolog E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205164.2 → NP_990495.1 homeobox protein Nkx-2.5

See identical proteins and their annotated locations for NP_990495.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000256

UniProtKB/Swiss-Prot

Q90788

Related

ENSGALP00010012749.1, ENSGALT00010022201.1

Conserved Domains (2) summary

COG5576
Location:127 → 229

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam00046
Location:126 → 175

Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052544.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

8816351..8818645 complement

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GenBank, FASTA, Sequence Viewer (Graphics)